Osimertinib-induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone

被引：1

作者：

Takao, Tomoaki ^{[1
]}

Tanaka, Kentaro ^{[1
]}

Shiraishi, Yoshimasa ^{[1
]}

Ota, Keiichi ^{[1
]}

Yoneshima, Yasuto ^{[1
]}

Iwama, Eiji ^{[1
]}

Okamoto, Isamu ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Res Inst Dis Chest, Fukuoka, Japan

来源：

CLINICAL LUNG CANCER | 2021年 / 22卷 / 05期

关键词：

Hyponatremia; Tyrosine kinase inhibitor; Syndrome of inappropriate secretion of antidiuretic hormone; Osimertinib; Non-small cell lung cancer;

D O I：

10.1016/j.cllc.2021.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We describe a case of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient treated with osimertinib. A 75-year-old woman was diagnosed with stage IV lung adenocarcinoma (T2aN0M1a) harboring an exon-19 deletion of epidermal growth factor receptor and was treated with osimertinib. After 14 days, she developed headache and nausea. The laboratory results fulfilled the diagnostic criteria of SIADH. Osimertinib was discontinued, and the patient was treated with sodium intake and fluid restriction. The serum sodium level improved within 1 week. After discontinuation of osimertinib treatment, the patient was started on gefitinib. She has been able to continue gefitinib treatment without development of hyponatremia. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：E784 / E785

页数：2

共 5 条

[1] Tyrosine kinase inhibitor-associated syndrome of inappropriate secretion of anti-diuretic hormone [J].

Hill, Jordan ;

Shields, Jenna ;

Passero, Vida .

JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2016, 22 (05) :729-732

[2] Syndrome of Inappropriate Secretion of Antidiuretic Hormone Associated with Imatinib [J].

Liapis, Konstantinos ;

Apostolidis, John ;

Charitaki, Evangelia ;

Panitsas, Fotios ;

Harhalakis, Nikolaos ;

Nikiforakis, Emmanuel .

ANNALS OF PHARMACOTHERAPY, 2008, 42 (12) :1882-1886

[3] CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer [J].

Reungwetwattana, Thanyanan ;

Nakagawa, Kazuhiko ;

Cho, Byoung Chul ;

Cobo, Manuel ;

Cho, Eun Kyung ;

Bertolini, Alessandro ;

Bohnet, Sabine ;

Zhou, Caicun ;

Lee, Ki Hyeong ;

Nogami, Naoyuki ;

Okamoto, Isamu ;

Leighl, Natasha ;

Hodge, Rachel ;

McKeown, Astrid ;

Brown, Andrew P. ;

Rukazenkov, Yuri ;

Ramalingam, Suresh S. ;

Vansteenkiste, Johan .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (33) :3290-+

[4] Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer [J].

Soria, J. -C. ;

Ohe, Y. ;

Vansteenkiste, J. ;

Reungwetwattana, T. ;

Chewaskulyong, B. ;

Lee, K. H. ;

Dechaphunkul, A. ;

Imamura, F. ;

Nogami, N. ;

Kurata, T. ;

Okamoto, I. ;

Zhou, C. ;

Cho, B. C. ;

Cheng, Y. ;

Cho, E. K. ;

Voon, P. J. ;

Planchard, D. ;

Su, W. -C. ;

Gray, J. E. ;

Lee, S. -M. ;

Hodge, R. ;

Marotti, M. ;

Rukazenkov, Y. ;

Ramalingam, S. S. ;

Boyer, Michael ;

Lee, Chee ;

Hughes, Brett ;

O'Byrne, Kenneth ;

Briggs, Peter ;

Milward, Michael ;

John, Thomas ;

Demedts, Ingel ;

Vansteenkiste, Johan ;

Bustin, Frederique ;

Barrios, Carlos Henrique ;

Timcheva, Constanta ;

Butts, Charles ;

Goss, Glenwood ;

Juergens, Rosalyn ;

Leighl, Natasha ;

Cheng, Susanna ;

Burkes, Ronald ;

Zhou, Caicun ;

Zhang, Helong ;

Shu, Yongqian ;

Cheng, Ying ;

Zhou, Qing ;

Li, Wei ;

Feng, Guosheng ;

He, Yong .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (02) :113-125

[5] Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations [J].

Verbalis, Joseph G. ;

Goldsmith, Steven R. ;

Greenberg, Arthur ;

Korzelius, Cynthia ;

Schrier, Robert W. ;

Sterns, Richard H. ;

Thompson, Christopher J. .

AMERICAN JOURNAL OF MEDICINE, 2013, 126 (10) :S5-S41

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