Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters

被引：19
作者：
Yuan, Lunzhi [1 ]
Zhou, Ming [1 ]
Ma, Jian [1 ]
Liu, Xuan [1 ]
Chen, Peiwen [2 ,3 ,4 ]
Zhu, Huachen [2 ,3 ,4 ]
Tang, Qiyi [5 ]
Cheng, Tong [1 ]
Guan, Yi [2 ,3 ,4 ]
Xia, Ningshao [1 ,6 ]
机构：
[1] Xiamen Univ, Sch Publ Hlth, Sch Life Sci,State Key Lab Mol Vaccinol & Mol Dia, Natl Inst Diagnost & Vaccine Dev Infect Dis, Xiamen, Fujian, Peoples R China
[2] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, State Key Lab Emerging Infect Dis, Hong Kong, Peoples R China
[3] Shantou Univ, Joint Inst Virol STU HKU, Joint Lab Int Collaborat Virol & Emerging Infect, Guangdong Hong Kong Joint Lab Emerging Infect Dis, Shantou, Guangdong, Peoples R China
[4] EKIH Pathogen Res Inst, Shenzhen, Guangdong, Peoples R China
[5] Howard Univ, Coll Med, Dept Microbiol, Washington, DC USA
[6] Chinese Acad Med Sci, Res Unit Frontier Technol Struct Vaccinol, Xiamen, Fujian, Peoples R China
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2022年 / 19卷 / 02期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
D O I：
10.1038/s41423-021-00793-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：290 / 292
页数：3
相关论文
共 9 条
[1]   Improved Survival Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Treated With Remdesivir and Dexamethasone. A Nationwide Population-Based Cohort Study [J].
Benfield, Thomas ;
Bodilsen, Jacob ;
Brieghel, Christian ;
Harboe, Zitta Barrella ;
Helleberg, Marie ;
Holm, Claire ;
Israelsen, Simone Bastrup ;
Jensen, Janne ;
Jensen, Tomas Ostergaard ;
Johansen, Isik Somuncu ;
Johnsen, Stine ;
Lindegaard, Birgitte ;
Lundgren, Jens ;
Meyer, Christian Niels ;
Mohey, Rajesh ;
Pedersen, Lars Moller ;
Nielsen, Henrik ;
Nielsen, Stig Lonberg ;
Obel, Niels ;
Omland, Lars Haukali ;
Podlekareva, Daria ;
Poulsen, Birgitte Klindt ;
Ravn, Pernille ;
Sandholdt, Haakon ;
Starling, Jonathan ;
Storgaard, Merete ;
Soborg, Christian ;
Sogaard, Ole Schmeltz ;
Tranborg, Torben ;
Wiese, Lothar ;
Christensen, Hanne Rolighed .
CLINICAL INFECTIOUS DISEASES, 2021, 73 (11) :2031-2036
[2]   After 62 years of regulating immunity, dexamethasone meets COVID-19 [J].
Cain, Derek W. ;
Cidlowski, John A. .
NATURE REVIEWS IMMUNOLOGY, 2020, 20 (10) :587-588
[3]   COVID-19: immunopathology and its implications for therapy [J].
Cao, Xuetao .
NATURE REVIEWS IMMUNOLOGY, 2020, 20 (05) :269-270
[4]  
Garcia-Beltran WF, 2021, CELL, V184, P2523, DOI 10.1016/j.cell.2021.04.006
[5]  
Horby P, 2021, NEW ENGL J MED, V384, P693, DOI [10.1056/NEJMoa2021436, 10.1056/NEJMoa2022926]
[6]  
Yang L, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00679-0
[7]   Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19 [J].
Yuan, Lunzhi ;
Zhu, Huachen ;
Zhou, Ming ;
Ma, Jian ;
Chen, Rirong ;
Yu, Liuqin ;
Chen, Wenjia ;
Hong, Wenshan ;
Wang, Jia ;
Chen, Yao ;
Wu, Kun ;
Hou, Wangheng ;
Zhang, Yali ;
Ge, Shengxiang ;
Chen, Yixin ;
Yuan, Quan ;
Tang, Qiyi ;
Cheng, Tong ;
Guan, Yi ;
Xia, Ningshao .
PROTEIN & CELL, 2022, 13 (01) :72-77
[8]   Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster [J].
Yuan, Lunzhi ;
Zhu, Huachen ;
Zhou, Ming ;
Ma, Jian ;
Chen, Rirong ;
Chen, Yao ;
Chen, Liqiang ;
Wu, Kun ;
Cai, Minping ;
Hong, Junping ;
Li, Lifeng ;
Liu, Che ;
Yu, Huan ;
Zhang, Yali ;
Wang, Jia ;
Zhang, Tianying ;
Ge, Shengxiang ;
Zhang, Jun ;
Yuan, Quan ;
Chen, Yixin ;
Tang, Qiyi ;
Chen, Honglin ;
Cheng, Tong ;
Guan, Yi ;
Xia, Ningshao .
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)
[9]   Coronaviruses - drug discovery and therapeutic options [J].
Zumla, Alimuddin ;
Chan, Jasper F. W. ;
Azhar, Esam I. ;
Hui, David S. C. ;
Yuen, Kwok-Yung .
NATURE REVIEWS DRUG DISCOVERY, 2016, 15 (05) :327-347
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