Gene regulation technologies in zebrafish

被引：14

作者：

Esengil, Hanife ^{[1
]}

Chen, James K. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA

来源：

MOLECULAR BIOSYSTEMS | 2008年 / 4卷 / 04期

关键词：

D O I：

10.1039/b718447f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Achieving the potential of zebrafish models in biomedical research is contingent on the development of reverse-genetic resources. This review describes current technologies for genetic perturbations in zebrafish, including an ecdysone receptor-based system that permits conditional transgene expression. Such methodologies promise to enable new zebrafish models for interrogating human physiology and disease.

引用

页码：300 / 308

页数：9

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