Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders

被引：80

作者：

Fineberg, Naomi A. ^{[1
,2
,3
]}

Hollander, Eric ^{[4
]}

Pallanti, Stefano ^{[5
,6
]}

Walitza, Susanne ^{[7
,8
,9
,10
]}

Grunblatt, Edna ^{[7
,8
,9
,10
]}

Dell'Osso, Bernardo Maria ^{[11
,12
,13
]}

Albert, Umberto ^{[14
]}

Geller, Daniel A. ^{[15
]}

Brakoulias, Vlasios ^{[16
,17
,18
]}

Janardhan Reddy, Y. C. ^{[19
]}

Arumugham, Shyam Sundar ^{[19
]}

Shavitt, Roseli G. ^{[20
]}

Drummond, Lynne ^{[21
]}

Grancini, Benedetta ^{[2
,11
]}

De Carlo, Vera ^{[2
,11
]}

Cinosi, Eduardo ^{[1
,2
]}

Chamberlain, Samuel R. ^{[22
,23
]}

Ioannidis, Konstantinos ^{[22
,23
]}

Rodriguez, Carolyn I. ^{[12
,24
]}

Garg, Kabir ^{[2
]}

Castle, David ^{[25
,26
]}

Van Ameringen, Michael ^{[27
,28
]}

Stein, Dan J. ^{[29
,30
]}

Carmi, Lior ^{[31
,32
]}

Zohar, Joseph ^{[31
,33
]}

Menchon, Jose M. ^{[34
]}

机构：

[1] Univ Hertfordshire, Hatfield, Herts, England

[2] Hertfordshire Partnership Univ NHS Fdn Trust, Welwyn Garden City, Herts, England

[3] Univ Cambridge, Sch Clin Med, Cambridge, England

[4] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10467 USA

[5] Univ Florence, Ist Neurosci, Florence, Italy

[6] Albert Einstein Coll Med, Bronx, NY 10467 USA

[7] Univ Zurich, Univ Hosp Psychiat Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland

[8] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

[9] Swiss Fed Inst Technol, Zurich, Switzerland

[10] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

[11] Univ Milan, Dept Biomed & Clin Sci Luigi Sacco, Osped Sacco Polo Univ, ASST Fatebenefratelli Sacco, Milan, Italy

[12] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[13] Univ Milan, CRC Aldo Ravelli Neurotechnol & Expt Brain Therap, Milan, Italy

[14] Univ Trieste, UCO Clin Psichiatr, Dept Med Surg & Hlth Sci, Trieste, Italy

[15] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA

[16] Blacktown Hosp, Western Sydney Local Hlth Dist, Western Sydney Obsess Compuls & Related Disorders, Blacktown, NSW, Australia

[17] Western Sydney Univ, Translat Res Hlth Inst THRI, Clin & Hlth Psychol Res Initiat CaHPR, Sydney, NSW, Australia

[18] Western Sydney Univ, Sch Med, Sydney, NSW, Australia

[19] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Psychiat, OCD Clin, Bengaluru, India

[20] Univ Sao Paulo, OCD Spectrum Disorders Program, Inst & Dept Psychiat, Hosp Clin,Fac Med, Sao Paulo, SP, Brazil

[21] Univ London, SW London & St Georges NHS Trust & St Georges, London, England

[22] Univ Cambridge, Dept Psychiat, Cambridge, England

[23] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England

[24] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA

[25] St Vincents Hosp, Melbourne, Vic, Australia

[26] Univ Melbourne, Melbourne, Vic, Australia

[27] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

[28] Hamilton Hlth Sci, Hamilton, ON, Canada

[29] Univ Cape Town, SA MRC Unit Risk & Resilience Mental Disorders, Dept Psychiat, Cape Town, South Africa

[30] Univ Cape Town, Neurosci Inst, Cape Town, South Africa

[31] Chaim Sheba Med Ctr, Post Trauma Ctr, Ramat Gan, Israel

[32] Interdisciplinary Ctr, Data Sci Inst, Herzliyya, Israel

[33] Tel Aviv Univ, Tel Aviv, Israel

[34] Univ Barcelona, Bellvitge Univ Hosp, IDIBELL, Dept Psychiat, Barcelona, Spain

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 2020年 / 35卷 / 04期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

evidence based; obsessive-compulsive disorder; position statement; treatments; SEROTONIN REUPTAKE INHIBITORS; TRANSCRANIAL MAGNETIC STIMULATION; COGNITIVE-BEHAVIORAL THERAPY; PLACEBO-CONTROLLED TRIAL; N-ACETYLCYSTEINE AUGMENTATION; IDEATION REDUCTION THERAPY; DEEP BRAIN-STIMULATION; EVIDENCE-BASED PHARMACOTHERAPY; POSTTRAUMATIC-STRESS-DISORDER; DOUBLE-BLIND;

D O I：

10.1097/YIC.0000000000000314

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this position statement, developed by The International College of Obsessive-Compulsive Spectrum Disorders, a group of international experts responds to recent developments in the evidence-based management of obsessive-compulsive disorder (OCD). The article presents those selected therapeutic advances judged to be of utmost relevance to the treatment of OCD, based on new and emerging evidence from clinical and translational science. Areas covered include refinement in the methods of clinical assessment, the importance of early intervention based on new staging models and the need to provide sustained well-being involving effective relapse prevention. The relative benefits of psychological, pharmacological and somatic treatments are reviewed and novel treatment strategies for difficult to treat OCD, including neurostimulation, as well as new areas for research such as problematic internet use, novel digital interventions, immunological therapies, pharmacogenetics and novel forms of psychotherapy are discussed.

引用

页码：173 / 193

页数：21

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