Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors

被引：17

作者：

Bazarov, Alexey V. ^{[1
,2
]}

Yaswen, Paul ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

[2] Univ Calif San Francisco, Dept Med, Div Hematol Oncol, San Francisco, CA 94143 USA

来源：

BREAST CANCER RESEARCH | 2011年 / 13卷 / 03期

关键词：

SUBTYPES; GENES;

D O I：

10.1186/bcr2873

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two recent reports identify ZNF703 as an oncogene driving selection of frequent chromosome 8p12 amplifications in luminal B breast tumors. The estrogen-responsive ZNF703 gene encodes a transcriptional cofactor that, when overexpressed, induces cell proliferation and interferes with transforming growth factor beta signaling. In MCF7 cells, increased ZNF703 expression results in activation of genes involved in stem cell self-renewal - while in primary human mammary epithelial cells, ZNF703 increases the ratio of luminal to basal progenitors. Expression of the murine homolog of ZNF703 reduces cell adhesion and promotes metastasis. ZNF703 overexpression thus alters regulation of proliferation and differentiation in luminal B tumors.

引用

页数：2

共 11 条

[1] Genomic and transcriptional aberrations linked to breast cancer pathophysiologies [J].

Chin, Koei ;

DeVries, Sandy ;

Fridlyand, Jane ;

Spellman, Paul T. ;

Roydasgupta, Ritu ;

Kuo, Wen-Lin ;

Lapuk, Anna ;

Neve, Richard M. ;

Qian, Zuwei ;

Ryder, Tom ;

Chen, Fanqing ;

Feiler, Heidi ;

Tokuyasu, Taku ;

Kingsley, Chris ;

Dairkee, Shanaz ;

Meng, Zhenhang ;

Chew, Karen ;

Pinkel, Daniel ;

Jain, Ajay ;

Ljung, Britt Marie ;

Esserman, Laura ;

Albertson, Donna G. ;

Waldman, Frederic M. ;

Gray, Joe W. .

CANCER CELL, 2006, 10 (06) :529-541

[2] Defining breast cancer prognosis based on molecular phenotypes: results from a large cohort study [J].

Dawood, Shaheenah ;

Hu, Rong ;

Homes, Michelle D. ;

Collins, Laura C. ;

Schnitt, Stuart J. ;

Connolly, James ;

Colditz, Graham A. ;

Tamimi, Rulla M. .

BREAST CANCER RESEARCH AND TREATMENT, 2011, 126 (01) :185-192

[3] A 1Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes [J].

Garcia, MJ ;

Pole, JCM ;

Chin, SF ;

Teschendorff, A ;

Naderi, A ;

Ozdag, H ;

Vias, M ;

Kranjac, T ;

Subkhankulova, T ;

Paish, C ;

Ellis, I ;

Brenton, JD ;

Edwards, PAW ;

Caldas, C .

ONCOGENE, 2005, 24 (33) :5235-5245

[4] ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium [J].

Holland, Daniel G. ;

Burleigh, Angela ;

Git, Anna ;

Goldgraben, Mae A. ;

Perez-Mancera, Pedro A. ;

Chin, Suet-Feung ;

Hurtado, Antonio ;

Bruna, Alejandro ;

Ali, H. Raza ;

Greenwood, Wendy ;

Dunning, Mark J. ;

Samarajiwa, Shamith ;

Menon, Suraj ;

Rueda, Oscar M. ;

Lynch, Andy G. ;

McKinney, Steven ;

Ellis, Ian O. ;

Eaves, Connie J. ;

Carroll, Jason S. ;

Curtis, Christina ;

Aparicio, Samuel ;

Caldas, Carlos .

EMBO MOLECULAR MEDICINE, 2011, 3 (03) :167-180

[5] Metastatic Behavior of Breast Cancer Subtypes [J].

Kennecke, Hagen ;

Yerushalmi, Rinat ;

Woods, Ryan ;

Cheang, Maggie Chon U. ;

Voduc, David ;

Speers, Caroline H. ;

Nielsen, Torsten O. ;

Gelmon, Karen .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (20) :3271-3277

[6] Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis [J].

Kwek, S. S. ;

Roy, R. ;

Zhou, H. ;

Climent, J. ;

Martinez-Climent, J. A. ;

Fridlyand, J. ;

Albertson, D. G. .

ONCOGENE, 2009, 28 (17) :1892-1903

[7] A novel subfamily of zinc finger genes involved in embryonic development [J].

Nakamura, M ;

Runko, AP ;

Sagerström, CG .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 93 (05) :887-895

[8] Nlz1/Znf703 acts as a repressor of transcription [J].

Nakamura, Mako ;

Choe, Seong-Kyu ;

Runko, Alexander P. ;

Gardner, Paul D. ;

Sagerstroem, Charles G. .

BMC DEVELOPMENTAL BIOLOGY, 2008, 8

[9] ZNF703 gene amplification at 8p12 specifies luminal B breast cancer [J].

Sircoulomb, Fabrice ;

Nicolas, Nathalie ;

Ferrari, Anthony ;

Finetti, Pascal ;

Bekhouche, Ismahane ;

Rousselet, Estelle ;

Lonigro, Aurelie ;

Adelaide, Jose ;

Baudelet, Emilie ;

Esteyries, Severine ;

Wicinski, Julien ;

Audebert, Stephane ;

Charafe-Jauffret, Emmanuelle ;

Jacquemier, Jocelyne ;

Lopez, Marc ;

Borg, Jean-Paul ;

Sotirious, Christos ;

Popovici, Cornel ;

Bertucci, Francois ;

Birnbaum, Daniel ;

Chaffanet, Max ;

Ginestier, Christophe .

EMBO MOLECULAR MEDICINE, 2011, 3 (03) :153-166

[10] Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization [J].

Slorach, Euan M. ;

Chou, Jonathan ;

Werb, Zena .

GENES & DEVELOPMENT, 2011, 25 (05) :471-484

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