Histopathological and Immunohistochemical Comparison of the Brain of Human Patients with Alzheimer's Disease and the Brain of Aged Dogs with Cognitive Dysfunction

被引：50

作者：

Yu, C. -H. ^{[1
]}

Song, G. -S. ^{[2
]}

Yhee, J. -Y. ^{[1
]}

Kim, J. -H. ^{[1
]}

Im, K. -S. ^{[1
]}

Nho, W-G. ^{[3
]}

Lee, J. -H. ^{[4
]}

Sur, J. -H. ^{[1
]}

机构：

[1] Konkuk Univ, Coll Vet Med, Small Anim Tumour Diagnost Ctr, Dept Vet Pathol, Seoul 143701, South Korea

[2] CJ Corp, Seoul 100743, South Korea

[3] Korean Natl Agr Coll, Dept Anim Sci, Hwaseong Si 445760, Gyeonggi Do, South Korea

[4] Konkuk Univ, Coll Vet Med, Dept Anat, Seoul 143701, South Korea

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2011年 / 145卷 / 01期

关键词：

Alzheimer's disease; amyloid-beta protein; cognitive dysfunction; dog; neurofibrillary tangle; tau; PAIRED HELICAL FILAMENTS; UBIQUITIN-PROTEASOME SYSTEM; AMYLOID PRECURSOR PROTEIN; SENILE PLAQUES; NEUROFIBRILLARY TANGLES; CANINE BRAIN; STAINING METHODS; DIFFUSE PLAQUES; NERVOUS-SYSTEM; BETA-PROTEIN;

D O I：

10.1016/j.jcpa.2010.11.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Alzheimer's disease (AD) is the most common progressive form of dementia in aged people. Microscopical changes in the brains of AD patients include the formation of senile plaques (SPs), neurofibrillary tangles (NFTs) and granulovacuolar degeneration and the deposition of amyloid-beta (A beta). Aged dogs are known to suffer from cognitive dysfunction and this state is associated with deposition of A beta in the brain. The aim of the present study was to investigate tau phosphorylation of neurons and astrocytes in the brain of aged dogs with progressive cognitive impairment. Changes in the brain of aged dogs with cognitive dysfunction were compared with those in the brain of patients with AD of Braak stage V. Immunohistochemically, A beta deposition, phosphorylated tau Ser396 (p-tau Ser396) and ubiquitin were observed in the parietal cortex and hippocampus of aged dogs with cognitive dysfunction. Astrocytes with expression of p-tau Ser396 and neurons with co-localization of p-tau Ser396 and ubiquitin were observed. Expression of p-tau Ser396 and accumulation of ubiquitin were significantly increased in the parietal cortex and dorsal part of the hippocampus of the brain of aged dogs when compared with expression of these molecules in human AD. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：45 / 58

页数：14

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