A facile, three-component domino protocol for the microwave-assisted synthesis of functionalized naphtho[2,3-b]furan-4,9-diones in water

被引：58

作者：

Prasanna, Pitchaimani ^{[1
]}

Balamurugan, Kamaraj ^{[1
]}

Perumal, Subbu ^{[1
]}

Carlos Menendez, J. ^{[2
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

[2] Univ Complutense, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain

来源：

GREEN CHEMISTRY | 2011年 / 13卷 / 08期

关键词：

ONE-POT SYNTHESIS; DIVERSITY-ORIENTED SYNTHESIS; STEP GENERAL-SYNTHESIS; MULTICOMPONENT REACTIONS; STRUCTURE ELUCIDATION; TABEBUIA-CASSINOIDES; ENERGY EFFICIENCY; ORGANIC-REACTIONS; 2-STEP SYNTHESIS; DRUG DISCOVERY;

D O I：

10.1039/c0gc00952k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A three-component domino reaction of 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and a pyridinium salt in the presence of ammonium acetate, under microwave irradiation and using water as solvent, furnished a library of novel 2-arylcarbonyl-3-aryl-4,9-dihydronaphtho-[2,3-b]furan-4,9-diones in good yields, in a transformation that presumably proceeds via an alpha,beta-unsaturated triketone generation/Michael addition/intramolecular cyclisation/air oxidation one-pot sequence.

引用

页码：2123 / 2129

页数：7

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