Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

被引：52

作者：

Fukai, Kota ^{[1
,2
]}

Harada, Sei ^{[1
,2
]}

Iida, Miho ^{[3
]}

Kurihara, Ayako ^{[1
,2
]}

Takeuchi, Ayano ^{[1
]}

Kuwabara, Kazuyo ^{[1
]}

Sugiyama, Daisuke ^{[1
]}

Okamura, Tomonori ^{[1
]}

Akiyama, Miki ^{[2
,4
]}

Nishiwaki, Yuji ^{[5
]}

Oguma, Yuko ^{[6
,7
]}

Suzuki, Asako ^{[2
]}

Suzuki, Chizuru ^{[2
]}

Hirayama, Akiyoshi ^{[2
]}

Sugimoto, Masahiro ^{[2
]}

Soga, Tomoyoshi ^{[2
,4
]}

Tomita, Masaru ^{[2
,4
]}

Takebayashi, Toru ^{[1
,2
,7
]}

机构：

[1] Keio Univ, Sch Med, Dept Prevent Med & Publ Hlth, Tokyo, Japan

[2] Keio Univ, Inst Adv Biosci, Tsuruoka, Yamagata, Japan

[3] Keio Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[4] Keio Univ, Fac Environm & Informat Studies, Fujisawa, Kanagawa, Japan

[5] Toho Univ, Fac Med, Dept Social Med, Div Environm & Occupat Hlth, Tokyo, Japan

[6] Keio Univ, Sports Med Res Ctr, Yokohama, Kanagawa, Japan

[7] Keio Univ, Grad Sch Hlth Management, Fujisawa, Kanagawa, Japan

来源：

PLOS ONE | 2016年 / 11卷 / 10期

基金：

日本学术振兴会;

关键词：

FOOD FREQUENCY QUESTIONNAIRE; DOSE-RESPONSE METAANALYSIS; CHAIN AMINO-ACIDS; INSULIN-RESISTANCE; ENERGY-EXPENDITURE; HEALTH-BENEFITS; ACTIVITY LEVEL; RISK; JAPANESE; DISEASE;

D O I：

10.1371/journal.pone.0164877

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective Physical activity is known to be preventive against various non-communicable diseases. We investigated the relationship between daily physical activity level and plasma metabo-lites using a targeted metabolomics approach in a population-based study. Methods A total of 1,193 participants (male, aged 35 to 74 years) with fasting blood samples were selected from the baseline survey of a cohort study. Information on daily total physical activity, classified into four levels by quartile of metabolic equivalent scores, and sedentary behavior, defined as hours of sitting per day, was collected through a self-administered questionnaire. Plasma metabolite concentrations were quantified by capillary electrophoresis mass spectrometry method. We performed linear regression analysis models with multi-variable adjustment and corrected p-values for multiple testing in the original population (n = 808). The robustness of the results was confirmed by replication analysis in a separate population (n = 385) created by random allocation. Results Higher levels of total physical activity were associated with various metabolite concentrations, including lower concentrations of amino acids and their derivatives, and higher concentrations of pipecolate (FDR p <0.05 in original population). The findings persisted after adjustment for age, body mass index, smoking, alcohol intake, and energy intake.

引用

页数：14

共 52 条

[41] Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss [J].