Microwave-Assisted Synthesis of 2-Substituted-4,5-diarylimidazoles from Benzoin Carboxylate Derivatives under Solvent-Free Conditions

被引：2

作者：

Li, Baozhi ^{[1
]}

Gu, Qiang ^{[1
]}

Zhao, Tianqi ^{[1
]}

He, Yuanhui ^{[1
]}

Tong, Yanan ^{[1
]}

Zhang, Yumin ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, Changchun 130012, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 32卷 / 08期

关键词：

2-substituted-4,5-di(aryl)imidazoles; benzoin carboxylates; microwave-assisted synthesis; solid-support; solvent-free; esterification; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; TETRASUBSTITUTED IMIDAZOLES; 2,4,5-TRIARYL IMIDAZOLES; IRRADIATION; 1,2-DIKETONES; ALDEHYDES; CATALYST;

D O I：

10.6023/cjoc1201101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzoin carboxylate derivatives were synthesized with the aromatic aldehydes as raw material in the presence of the catalyst VB1. And then, benzoin carboxylate derivatives reacted with different acylating reagents under mild reaction conditions, and benzoin carboxylates were obtained. Further, 2-substituted-4,5-di(aryl)imidazoles were produced from benzoin carboxylates in the presence of solid supports Al2O3 under solvent-free and microware assisted condition, and seven of them have not been reported. The reaction possessed many advantages such as mild reaction conditions, short reaction time, and no organic solvents consumed. Therefore, it is a facile and efficient synthetic method. Moreover, the synthesized compounds were characterized by H-1 NMR, C-13 NMR, IR, HRMS techniques.

引用

页码：1459 / 1467

页数：9

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