Protein Kinases and Parkinson's Disease

被引：25

作者：

Mehdi, Syed Jafar ^{[1
]}

Rosas-Hernandez, Hector ^{[2
]}

Cuevas, Elvis ^{[2
]}

Lantz, Susan M. ^{[2
]}

Barger, Steven W. ^{[1
,3
]}

Sarkar, Sumit ^{[2
]}

Paule, Merle G. ^{[2
]}

Ali, Syed F. ^{[2
]}

Imam, Syed Z. ^{[1
,2
]}

机构：

[1] Univ Arkansas Med Sci, Dept Geriatr, Little Rock, AR 72205 USA

[2] US FDA, Div Neurotoxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

[3] Cent Arkansas Vet Healthcare Syst, Ctr Geriatr Res Educ & Clin, Little Rock, AR 72205 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 09期

关键词：

Parkinson's disease; dopamine; tyrosine kinase; serine/threonine kinase; kinase inhibitors; CEREBELLAR GRANULE NEURONS; DOPAMINERGIC CELL-DEATH; G2019S LRRK2 MUTATION; JNK ACTIVATION; MOUSE MODEL; IN-VIVO; C-ABL; SIGNALING PATHWAY; INDUCED APOPTOSIS; TYROSINE KINASES;

D O I：

10.3390/ijms17091585

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson's disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing because numerous serine/threonine and tyrosine kinases have been implicated in the pathobiology of Parkinson's disease. This review focuses on various kinase-dependent pathways associated with the expression of Parkinson's disease pathology, and evaluates how inhibitors of these pathways might play a major role as effective therapeutic molecules.

引用

页数：12

共 93 条

[91] Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene [J].

Yang, DD ;

Kuan, CY ;

Whitmarsh, AJ ;

Rincon, M ;

Zheng, TS ;

Davis, RJ ;

Rakic, P ;

Flavell, RA .

NATURE, 1997, 389 (6653) :865-870

[92] Secalonic acid A protects dopaminergic neurons from 1-methyl-4-phenylpyridinium (MPP+)-induced cell death via the mitochondrial apoptotic pathway [J].

Zhai, Aifeng ;

Zhu, Xiaonan ;

Wang, Xuelan ;

Chen, Ruzhu ;

Wang, Hai .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 713 (1-3) :58-67

[93] Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology [J].

Zimprich, A ;

Biskup, S ;

Leitner, P ;

Lichtner, P ;

Farrer, M ;

Lincoln, S ;

Kachergus, J ;

Hulihan, M ;

Uitti, RJ ;

Calne, DB ;

Stoessl, AJ ;

Pfeiffer, RF ;

Patenge, N ;

Carbajal, IC ;

Vieregge, P ;

Asmus, F ;

Müller-Myhsok, B ;

Dickson, DW ;

Meitinger, T ;

Strom, TM ;

Wszolek, ZK ;

Gasser, T .

NEURON, 2004, 44 (04) :601-607

← 1 2 3 4 5 6 7 8 9 10 →