Chemical composition, antimicrobial and cytotoxic activities of essential oils fromSchinus polygamus(Cav.) cabrera leaf and bark grown in Egypt

Schinus polygamus(Anacardiaceae) is a shrub cultivated in Egypt for ornamental purpose. The major components of bark oil weredl-limonene (29.74%), followed by myrtenal (14.02%) and caryophyllene oxide (11.34%), whileE-caryophyllene (55.86%),dl-limonene (27.71%) and beta-pinene (3.54%) were predominant in the leaf oil. These isolated oils were screened for their antimicrobial activity againstStaphylococcus aureusATCC 33591, Staphylococcus aureusATCC 29213,Escherichia coliATCC 25922,Pseudomonas aeruginosaATCC 10145,Candida albicansMTCC183 andAspergillus nigerNRRL 595, and two clinical isolates ofStaphylococcus aureus. The leaf oil showed a remarkable inhibitory effect against all tested bacterial strains with minimum inhibitory concentration (MIC) range of 25 to 300 mu g/mL, while the bark oil was active againstEscherichia coliATCC 25922 andPseudomonas aeruginosaATCC 10145 only. Furthermore, the bark and leaf oils revealed potent cytotoxic effects on HepG2 and Caco-2 cells with IC(50)values of 1.56 to 24.12 mu g/mL.