One evidence base; three stories: do opioids relieve chronic breathlessness?

被引：77

作者：

Ekstrom, Magnus ^{[1
]}

Bajwah, Sabrina ^{[2
]}

Bland, J. Martin ^{[3
]}

Currow, David C. ^{[4
]}

Hussain, Jamilla ^{[5
]}

Johnson, Miriam J. ^{[5
]}

机构：

[1] Lund Univ, Dept Clin Sci, Div Resp Med & Allergol, SE-22100 Lund, Sweden

[2] Kings Coll London, Cicely Saunders Inst, London, England

[3] Univ York, Dept Hlth Sci, York, N Yorkshire, England

[4] Flinders Univ S Australia, Discipline Palliat & Support Serv, Adelaide, SA, Australia

[5] Univ Hull, Hull York Med Sch, Kingston Upon Hull, N Humberside, England

来源：

THORAX | 2018年 / 73卷 / 01期

基金：

美国国家卫生研究院;

关键词：

METAANALYSIS COMBINING PARALLEL; OVER CLINICAL-TRIALS; MANAGEMENT; DYSPNEA;

D O I：

10.1136/thoraxjnl-2016-209868

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al. We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 included trials) and added a risk-of-bias criterion (sample size). When re-analysed to account for crossover data, opioids decreased breathlessness (standardised mean differences -0.32; -0.18 to -0.47; I-2=44.8%) representing a clinically meaningful reduction of 0.8 points (0-10 numerical rating scale), consistent across meta-analyses.

引用

页码：88 / 90

页数：3

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