The role of SMG-1 in nonsense-mediated mRNA decay

被引：64
|
作者：
Yamashita, A
Kashima, I
Ohno, S
机构：
[1] Yokohama City Univ, Sch Med, Dept Mol Biol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
[2] Grad Sch Med Sci, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2005年 / 1754卷 / 1-2期
关键词：
NMD; PTC; PIKK; SMG-1; phosphorylation; dephosphorylation;
D O I：
10.1016/j.bbapap.2005.10.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
SMG-1, a member, of the PIKK (phosphoinositide 3-kinase related kinases) family, plays a critical role in the mRNA quality control system termed nonsense-mediated mRNA decay (NMD). NMD protects the cells from the accumulation of aberrant mRNAs with premature termination codons (PTCs) that encode nonfunctional or potentially harmful truncated proteins. SMG-1 directly phosphorylates Upf1, another key component of NMD, and this phosphorylation 'occurs upon recognition of PTC on post-spliced mRNA during the initial round of translation. At present, a variety of tools are available that can specifically suppress NMD, and it is possible to examine the contribution of NMD in a variety of physiological and pathological conditions. (c) 2005 Elsevier B.V All rights reserved.
引用
收藏
页码：305 / 315
页数：11
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