Decreased olfactory bulb volume in idiopathic Parkinson's disease detected by 3.0-Tesla magnetic resonance imaging

被引：67

作者：

Brodoehl, Stefan ^{[1
,3
]}

Klingner, Carsten ^{[1
,3
]}

Volk, Gerd F. ^{[2
]}

Bitter, Thomas ^{[2
]}

Witte, Otto W. ^{[1
,3
]}

Redecker, Christoph ^{[1
]}

机构：

[1] Jena Univ Hosp, Hans Berger Dept Neurol, D-07747 Jena, Germany

[2] Jena Univ Hosp, Dept Otorhinolaryngol, D-07747 Jena, Germany

[3] Univ Jena, Brain Imaging Ctr, Jena, Germany

来源：

MOVEMENT DISORDERS | 2012年 / 27卷 / 08期

关键词：

Parkinson's disease; olfactory bulb; MRI; EARLY ALZHEIMERS-DISEASE; ODOR IDENTIFICATION; NEURODEGENERATIVE DISEASE; COGNITIVE IMPAIRMENT; NORMATIVE DATA; TEMPORAL-LOBE; GRAY-MATTER; DYSFUNCTION; TRACT; MR;

D O I：

10.1002/mds.25087

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A number of neuropathological studies have demonstrated that the olfactory system is among the first brain regions affected in Parkinson's disease (PD). These findings correlate with pathophysiological and pathological data that show a loss in olfactory bulb (OB) volume in patients with PD. However, to date, MRI has not been a reliable method for the in vivo detection of this volumetric loss in PD. Using a 3.0-Tesla MRI constructive interference in the steady-state sequence, OB volume was evaluated in patients with PD (n = 16) and healthy control subjects (n = 16). A significant loss of OB volume was observed in patients with PD, compared to the healthy control group (91.2 +/- 15.72 versus 131.4 +/- 24.56 mm3, respectively). Specifically, decreased height of the left OB appears to be a reliable parameter that is adaptable to clinical practice and significantly correlates with OB volume loss in patients with idiopathic PD. Measuring both the volume and height of the OB by MRI may be a valuable method for the clinical investigation of PD. (c) 2012 Movement Disorder Society

引用

页码：1019 / 1025

页数：7

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