Visible Light-Induced Unactivated δ-C(sp3)-H Amination of Alcohols Catalyzed by Iron

被引：19
作者：
Jue, Zhaofan [1 ]
Huang, Yahao [1 ]
Qian, Jiahui [1 ]
Hu, Peng [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem, Lehn Inst Funct Mat, Guangzhou 510006, Peoples R China
来源：
CHEMSUSCHEM | 2022年 / 15卷 / 20期
基金：
中国国家自然科学基金;
关键词：
amination; C-H activation; hydrogen transfer; iron; photocatalysis; HYDROGEN-ATOM; PHOTOREDOX CATALYSIS; FUNCTIONALIZATION; HETEROARYLATION; GENERATION; RADICALS; COMPLEX; ALKANES; BONDS; MONO;
D O I：
10.1002/cssc.202201241
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An iron-catalyzed remote C(sp(3))-H amination of alcohols through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate delta-C(sp(3))-N bonds from primary, secondary, and tertiary alcohols under mild conditions. A wide substrate scope and a good functional group tolerance are presented. Mechanistic studies show that a LMCT course of an Fe-OR species and a chlorine radical-induced hydrogen abstraction of an alcohol are possible to generate the alkoxy radical intermediate.
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页数：6
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