Intermedin (adrenomedullin2) stabilizes the endothelial barrier and antagonizes thrombin-induced barrier failure in endothelial cell monolayers

被引：54
作者：
Aslam, M. [1 ]
Pfeil, U. [2 ]
Guenduez, D. [3 ]
Rafiq, A. [2 ]
Kummer, W. [2 ]
Piper, H. M. [1 ]
Noll, T. [1 ]
机构：
[1] Univ Giessen, Inst Physiol, D-35392 Giessen, Germany
[2] Univ Giessen, Inst Anat & Zellbiol, D-35392 Giessen, Germany
[3] Uniklinikum Giessen & Marburg, Abt Kardiol Angiol, Zentrum Innere Med, Giessen, Germany
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 165卷 / 01期
关键词：
RAMP2; CGRP8-37; intermedin; Rac1; thrombin; PEPTIDE FAMILY PEPTIDE; RECEPTOR-LIKE-RECEPTOR; CALCITONIN-RECEPTOR; CAMP ACCUMULATION; INDUCED INCREASE; IN-VITRO; PERMEABILITY; RAT; GENE; RHO;
D O I：
10.1111/j.1476-5381.2011.01540.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
BACKGROUND AND PURPOSE Intermedin is a member of the calcitonin gene-related-peptide (CGRP) family expressed in endothelial cells and acts via calcitonin receptor-like receptors (CLRs). Here we have analysed the receptors for intermedin and its effect on the endothelial barrier in monolayers of human umbilical vein endothelial cells (HUVECs).
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收藏
页码：208 / 222
页数：15
相关论文
共 42 条
[31]   Hemodynamic, Hormonal, and Renal Actions of Adrenomedullin 2 in Experimental Heart Failure [J].
Rademaker, Miriam T. ;
Charles, Christopher J. ;
Nicholls, Gary ;
Richards, A. Mark .
CIRCULATION-HEART FAILURE, 2008, 1 (02) :134-142
[32]   Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes [J].
Roh, J ;
Chang, CL ;
Bhalla, A ;
Klein, C ;
Hsu, SYT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (08) :7264-7274
[33]   ROLE OF ACTIN AND MYOSIN IN THE CONTROL OF PARACELLULAR PERMEABILITY IN PIG, RAT AND HUMAN VASCULAR ENDOTHELIUM [J].
SCHNITTLER, HJ ;
WILKE, A ;
GRESS, T ;
SUTTORP, N ;
DRENCKHAHN, D .
JOURNAL OF PHYSIOLOGY-LONDON, 1990, 431 :379-401
[34]   Novel fish-derived adrenomedullin in mammals: structure and possible function [J].
Takei, Y ;
Hyodo, S ;
Katafuchi, T ;
Minamino, N .
PEPTIDES, 2004, 25 (10) :1643-1656
[35]   Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator [J].
Takei, Y ;
Inoue, K ;
Ogoshi, M ;
Kawahara, T ;
Bannai, H ;
Miyano, S .
FEBS LETTERS, 2004, 556 (1-3) :53-58
[36]   Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture [J].
Takhshid, Mohammad A. ;
Poyner, David R. ;
Chabot, Jean-Guy ;
Fournier, Alain ;
Ma, Weiya ;
Zheng, Wen-Hua ;
Owji, Ali A. ;
Quirion, Remi .
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 148 (04) :459-468
[37]   Regulation of endothelial junctional permeability [J].
Vandenbroucke, Emily ;
Mehta, Dolly ;
Minshall, Richard ;
Malik, Asrar B. .
CONTROL AND REGULATION OF TRANSPORT PHENOMENA IN THE CARDIAC SYSTEM, 2008, 1123 :134-145
[38]   Rho GTPases and the regulation of endothelial permeability [J].
Wojciak-Stothard, B ;
Ridley, AJ .
VASCULAR PHARMACOLOGY, 2002, 39 (4-5) :187-199
[39]  
Wójciak-Stothard B, 2001, J CELL SCI, V114, P1343
[40]   Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines [J].
Wunder, Frank ;
Rebmann, Annegret ;
Geerts, Andreas ;
Kalthof, Bernd .
MOLECULAR PHARMACOLOGY, 2008, 73 (04) :1235-1243
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