Intermedin (adrenomedullin2) stabilizes the endothelial barrier and antagonizes thrombin-induced barrier failure in endothelial cell monolayers

被引：54
作者：
Aslam, M. [1 ]
Pfeil, U. [2 ]
Guenduez, D. [3 ]
Rafiq, A. [2 ]
Kummer, W. [2 ]
Piper, H. M. [1 ]
Noll, T. [1 ]
机构：
[1] Univ Giessen, Inst Physiol, D-35392 Giessen, Germany
[2] Univ Giessen, Inst Anat & Zellbiol, D-35392 Giessen, Germany
[3] Uniklinikum Giessen & Marburg, Abt Kardiol Angiol, Zentrum Innere Med, Giessen, Germany
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 165卷 / 01期
关键词：
RAMP2; CGRP8-37; intermedin; Rac1; thrombin; PEPTIDE FAMILY PEPTIDE; RECEPTOR-LIKE-RECEPTOR; CALCITONIN-RECEPTOR; CAMP ACCUMULATION; INDUCED INCREASE; IN-VITRO; PERMEABILITY; RAT; GENE; RHO;
D O I：
10.1111/j.1476-5381.2011.01540.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
BACKGROUND AND PURPOSE Intermedin is a member of the calcitonin gene-related-peptide (CGRP) family expressed in endothelial cells and acts via calcitonin receptor-like receptors (CLRs). Here we have analysed the receptors for intermedin and its effect on the endothelial barrier in monolayers of human umbilical vein endothelial cells (HUVECs).
引用
收藏
页码：208 / 222
页数：15
相关论文
共 42 条
[11]   Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP [J].
de Rooij, J ;
Zwartkruis, FJT ;
Verheijen, MHG ;
Cool, RH ;
Nijman, SMB ;
Wittinghofer, A ;
Bos, JL .
NATURE, 1998, 396 (6710) :474-477
[12]   The role of adherens junctions and VE-cadherin in the control of vascular permeability [J].
Dejana, Elisabetta ;
Orsenigo, Fabrizio ;
Lampugnani, Maria Grazia .
JOURNAL OF CELL SCIENCE, 2008, 121 (13) :2115-2122
[13]   Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo [J].
Dunworth, William P. ;
Fritz-Six, Kimberly L. ;
Caron, Kathleen M. .
PEPTIDES, 2008, 29 (12) :2243-2249
[14]   The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor [J].
Fraser, NJ ;
Wise, A ;
Brown, J ;
McLatchie, LM ;
Main, MJ ;
Foord, SM .
MOLECULAR PHARMACOLOGY, 1999, 55 (06) :1054-1059
[15]   Adrenomedullin signaling is necessary for murine lymphatic vascular development [J].
Fritz-Six, Kimberly L. ;
Dunworth, William P. ;
Li, Manyu ;
Caron, Kathleen M. .
JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (01) :40-50
[16]   THROMBIN-INDUCED INCREASE IN ALBUMIN PERMEABILITY ACROSS THE ENDOTHELIUM [J].
GARCIA, JGN ;
SIFLINGERBIRNBOIM, A ;
BIZIOS, R ;
DELVECCHIO, PJ ;
FENTON, JW ;
MALIK, AB .
JOURNAL OF CELLULAR PHYSIOLOGY, 1986, 128 (01) :96-104
[17]   Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes [J].
Hay, DL ;
Christopoulos, G ;
Christopoulos, A ;
Poyner, DR ;
Sexton, PM .
MOLECULAR PHARMACOLOGY, 2005, 67 (05) :1655-1665
[18]   The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors [J].
Hay, DL ;
Conner, AC ;
Howitt, SG ;
Smith, DM ;
Poyner, DR .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2004, 22 (1-2) :105-113
[19]   CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors:: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS [J].
Hay, DL ;
Howitt, SG ;
Conner, AC ;
Schindler, M ;
Smith, DM ;
Poyner, DR .
BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140 (03) :477-486
[20]   Adrenomedullin reduces endothelial hyperpermeability [J].
Hippenstiel, S ;
Witzenrath, M ;
Schmeck, B ;
Hocke, A ;
Krisp, M ;
Krüll, M ;
Seybold, J ;
Seeger, W ;
Rascher, W ;
Schütte, H ;
Suttorp, N .
CIRCULATION RESEARCH, 2002, 91 (07) :618-625
12345