Intermedin (adrenomedullin2) stabilizes the endothelial barrier and antagonizes thrombin-induced barrier failure in endothelial cell monolayers

被引：54
作者：
Aslam, M. [1 ]
Pfeil, U. [2 ]
Guenduez, D. [3 ]
Rafiq, A. [2 ]
Kummer, W. [2 ]
Piper, H. M. [1 ]
Noll, T. [1 ]
机构：
[1] Univ Giessen, Inst Physiol, D-35392 Giessen, Germany
[2] Univ Giessen, Inst Anat & Zellbiol, D-35392 Giessen, Germany
[3] Uniklinikum Giessen & Marburg, Abt Kardiol Angiol, Zentrum Innere Med, Giessen, Germany
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 165卷 / 01期
关键词：
RAMP2; CGRP8-37; intermedin; Rac1; thrombin; PEPTIDE FAMILY PEPTIDE; RECEPTOR-LIKE-RECEPTOR; CALCITONIN-RECEPTOR; CAMP ACCUMULATION; INDUCED INCREASE; IN-VITRO; PERMEABILITY; RAT; GENE; RHO;
D O I：
10.1111/j.1476-5381.2011.01540.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
BACKGROUND AND PURPOSE Intermedin is a member of the calcitonin gene-related-peptide (CGRP) family expressed in endothelial cells and acts via calcitonin receptor-like receptors (CLRs). Here we have analysed the receptors for intermedin and its effect on the endothelial barrier in monolayers of human umbilical vein endothelial cells (HUVECs).
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收藏
页码：208 / 222
页数：15
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