Baicalin Down-regulates the Expression of Macrophage Migration Inhibitory Factor (MIF) Effectively for Rats with Ulcerative Colitis

被引：61
作者：
Dai, Shi-Xue [1 ,2 ]
Zou, Ying [1 ,3 ]
Feng, Yan-Ling [2 ]
Liu, Hong-Bo [2 ]
Zheng, Xue-Bao [2 ]
机构：
[1] So Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China
[2] Guangdong Med Coll, Res Inst Tradit Chinese Med, Zhanjiang 524023, Peoples R China
[3] Guangdong Med Coll, Canc Res Ctr, Dongguan 523808, Peoples R China
来源：
PHYTOTHERAPY RESEARCH | 2012年 / 26卷 / 04期
基金：
中国国家自然科学基金;
关键词：
ulcerative colitis; baicalin; mesalazine; macrophage migration inhibitory factor; INFLAMMATORY-BOWEL-DISEASE; SODIUM-INDUCED COLITIS; ACID-INDUCED COLITIS; PROTECTS MICE; TNF-ALPHA; CELLS; MESALAZINE; MCP-1; ANTIBODY; MODELS;
D O I：
10.1002/ptr.3581
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The purpose of this study was to investigate whether baicalin, a Chinese herbal extract, down-regulates the expression of macrophage migration inhibitory factor (MIF), an inflammatory factor that regulates the function of macrophages (MF), in rats with trinitrobenzene sulphonic acid (TNBS)-induced ulcerative colitis (UC). The results showed that baicalin simultaneously down-regulated the expression of MIF, the quantity of MFs and the amount of MF-related cytokines, including macrophage chemotactic factor-1 (MCP-1, CCL2) and macrophage inflammatory protein-3a (MIP-3a, CCL20), in rats with UC. There was no statistical difference between baicailin and mesalazine in down-regulating the expression of MIF. Our study demonstrated that baicalin, an inexpensive but effective monomer, could be a new and alternative pharmaceutical for UC. Copyright (C) 2011 John Wiley & Sons, Ltd.
引用
收藏
页码：498 / 504
页数：7
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