Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer

被引：218
作者：
Cockbain, A. J. [1 ]
Toogood, G. J. [2 ]
Hull, M. A. [1 ]
机构：
[1] Univ Leeds, Leeds Inst Mol Med, Leeds, W Yorkshire, England
[2] St James Univ Hosp, Dept Hepatobiliary Surg, Leeds Teaching Hosp NHS Trust, Leeds LS9 7TF, W Yorkshire, England
来源：
GUT | 2012年 / 61卷 / 01期
关键词：
DIETARY FISH-OIL; ABERRANT CRYPT FOCI; COMMUNITY-ACQUIRED PNEUMONIA; INDUCED COLON CARCINOGENESIS; RECTAL CELL-PROLIFERATION; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; TUMOR-GROWTH; RAT COLON; N-3; PUFA;
D O I：
10.1136/gut.2010.233718
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Omega (omega)-3 polyunsaturated fatty acids (PUFAs) are naturally occurring substances that are well tolerated and have been used extensively for the prevention of cardiovascular disease. More recently, omega-3 PUFAs have been recognised to have anticancer activity. There is also evidence suggesting improved efficacy and/or tolerability of conventional cancer chemotherapy when administered with omega-3 PUFAs. The purpose of this review is to (i) describe the mechanisms by which omega-3 PUFAs are thought to have antineoplastic activity, (ii) review published preclinical and clinical studies that support anti-colorectal cancer activity and (iii) summarise current clinical trials investigating the potential therapeutic role(s) of omega-3 PUFAs at different stages of colorectal carcinogenesis, from adenoma (polyp) prevention to treatment of established malignant disease and prevention of cancer recurrence.
引用
收藏
页码：135 / 149
页数：15
相关论文
共 141 条
  • [21] α-linolenic acid metabolism in men and women:: nutritional and biological implications
    Burdge, G
    [J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2004, 7 (02) : 137 - 144
  • [22] Byers Tim, 1996, Cancer, V78, P1612, DOI 10.1002/(SICI)1097-0142(19961001)78:7<1612::AID-CNCR43>3.0.CO
  • [23] 2-#
  • [24] Dietary fish oil suppresses human colon tumour growth in athymic mice
    Calder, PC
    Davis, J
    Yaqoob, P
    Pala, H
    Thies, F
    Newsholme, EA
    [J]. CLINICAL SCIENCE, 1998, 94 (03) : 303 - 311
  • [25] Immunomodulation by omega-3 fatty acids
    Calder, Philip C.
    [J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2007, 77 (5-6): : 327 - 335
  • [26] n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: Molecular mechanisms involved
    Calviello, G.
    Serini, S.
    Piccioni, E.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2007, 14 (29) : 3059 - 3069
  • [27] n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1α induction pathway
    Calviello, G
    Di Nicuolo, F
    Gragnoli, S
    Piccioni, E
    Serini, S
    Maggiano, N
    Tringali, G
    Navarra, P
    Ranelletti, FO
    Palozza, P
    [J]. CARCINOGENESIS, 2004, 25 (12) : 2303 - 2310
  • [28] Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil
    Calviello, G
    Di Nicuolo, F
    Serini, S
    Piccioni, E
    Boninsegna, A
    Maggiano, N
    Ranelletti, FO
    Palozza, P
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2005, 55 (01) : 12 - 20
  • [29] Antineoplastic Effects of N-3 Polyunsaturated Fatty Acids in Combination With Drugs and Radiotherapy: Preventive and Therapeutic Strategies
    Calviello, G.
    Serini, S.
    Piccioni, E.
    Pessina, G.
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2009, 61 (03): : 287 - 301
  • [30] Docosahexaenoic acid induces proteasome-dependent degradation of β-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2
    Calviello, Gabriella
    Resci, Federica
    Serini, Simona
    Piccioni, Elisabetta
    Toesca, Amelia
    Boninsegna, Alma
    Monego, Giovanni
    Ranelletti, Franco O.
    Palozza, Paola
    [J]. CARCINOGENESIS, 2007, 28 (06) : 1202 - 1209
12345678910