Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer

被引：220
作者：
Cockbain, A. J. [1 ]
Toogood, G. J. [2 ]
Hull, M. A. [1 ]
机构：
[1] Univ Leeds, Leeds Inst Mol Med, Leeds, W Yorkshire, England
[2] St James Univ Hosp, Dept Hepatobiliary Surg, Leeds Teaching Hosp NHS Trust, Leeds LS9 7TF, W Yorkshire, England
来源：
GUT | 2012年 / 61卷 / 01期
关键词：
DIETARY FISH-OIL; ABERRANT CRYPT FOCI; COMMUNITY-ACQUIRED PNEUMONIA; INDUCED COLON CARCINOGENESIS; RECTAL CELL-PROLIFERATION; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; TUMOR-GROWTH; RAT COLON; N-3; PUFA;
D O I：
10.1136/gut.2010.233718
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Omega (omega)-3 polyunsaturated fatty acids (PUFAs) are naturally occurring substances that are well tolerated and have been used extensively for the prevention of cardiovascular disease. More recently, omega-3 PUFAs have been recognised to have anticancer activity. There is also evidence suggesting improved efficacy and/or tolerability of conventional cancer chemotherapy when administered with omega-3 PUFAs. The purpose of this review is to (i) describe the mechanisms by which omega-3 PUFAs are thought to have antineoplastic activity, (ii) review published preclinical and clinical studies that support anti-colorectal cancer activity and (iii) summarise current clinical trials investigating the potential therapeutic role(s) of omega-3 PUFAs at different stages of colorectal carcinogenesis, from adenoma (polyp) prevention to treatment of established malignant disease and prevention of cancer recurrence.
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收藏
页码：135 / 149
页数：15
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