Hot and cold natures and some parameters of neuroendocrine and immune systems in traditional Iranian medicine: A preliminary study

被引:60
作者
Shahabi, Shahram [1 ]
Hassan, Zuhair Muhammad [2 ]
Mahdavi, Mehdi [2 ]
Dezfouli, Mahya [3 ]
Rahvar, Monireh Torabi [3 ]
Naseri, Mohsen [4 ]
Jazani, Nima Hosseni [1 ]
Khalkhali, Hamid Reza [5 ]
机构
[1] Urmia Univ Med Sci, Fac Med, Dept Immunol Microbiol & Genet, Orumiyeh, Iran
[2] Tarbiat Modares Univ, Fac Med Sci, Dept Immunol, Tehran, Iran
[3] Univ Tehran Med Sci, Immunol Asthma & Allergy Res Inst, Tehran, Iran
[4] Shahed Univ, Herbal Med Res Ctr, Dept Tradit Iranian Med, Tehran, Iran
[5] Urmia Univ Med Sci, Fac Med, Dept Occupat Hlth, Orumiyeh, Iran
关键词
D O I
10.1089/acm.2007.0693
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Aim: The purpose of this study was to assess differences in persons of a Hot or Cold nature (according to traditional Iranian medicine), in terms of changes in their neuroendocrine and immune systems. Materials and methods: Thirty-seven (37) male volunteers (20-40 years old) were divided into two groups, by whether they had a Hot or Cold nature. In addition, the Warmth/Coldness ratio of all the volunteers was assessed. Plasma concentrations of epinephrine, norepinephrine and cortisol, and also the concentrations of interferon (IFN)-gamma and interleukin (IL)-4 produced by peripheral blood mononuclear cells stimulated by mitogen were measured. Results: The results showed that norepinephrine/epinephrine and norepinephrine/cortisol ratios were significantly higher, and that there was a borderline significantly increased IL-4/IFN-gamma ratio in the Hot nature group compared with those in the Cold nature group. In addition, there was a significant linear positive correlation between the norepinephrine/epinephrine and Warmth/Coldness ratios and a significant nonlinear association between the IL-4/IFN-gamma and Warmth/Coldness ratios. Conclusions: It can be deduced that the persons of a Hot nature had more sympathetic nervous system activity, less adrenal sympathetic, adrenal corticosteroid, and parasympathetic nervous system activities and more deviation of the immune system toward T-helper (Th)2 responses than the persons of a Cold nature. Moreover, the activity of the sympathetic nervous system was increased and adrenal sympathetic was decreased with an increasing Warmth/Coldness ratio. Furthermore, when the person's nature veered toward extreme Warmth or extreme Coldness, the deviation of the immune system toward Th2-like responses was greater, but this increased deviation was much more marked when veering toward extreme Warmth than toward extreme Coldness.
引用
收藏
页码:147 / 156
页数:10
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