Pro- and antiangiogenic therapies: current status and clinical implications

被引：62

作者：

Rust, Ruslan ^{[1
,2
]}

Gantner, Christina ^{[3
]}

Schwab, Martin E. ^{[1
,2
]}

机构：

[1] Univ Zurich, Brain Res Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[2] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Zurich, Switzerland

[3] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Dept Biol, Zurich, Switzerland

来源：

FASEB JOURNAL | 2019年 / 33卷 / 01期

关键词：

vascularization; vascular repair; stroke; retinopathy; cancer; ENDOTHELIAL GROWTH-FACTOR; METASTATIC COLORECTAL-CANCER; CHRONIC MYOCARDIAL-ISCHEMIA; MESENCHYMAL STEM-CELLS; ANTI-VEGF THERAPY; VASCULAR-PERMEABILITY; PROGENITOR CELLS; IN-VITRO; INTRAVITREAL INJECTION; PROMOTES ANGIOGENESIS;

D O I：

10.1096/fj.201800640RR

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood vessels nurture every part of the human body. Consequently, abnormalities in the vasculature are closely associated with a variety of diseases, including cerebral stroke, heart disease, retinopathy, and cancer. Pro- or antiangiogenic therapies can influence these diseases by regulating the growth of new blood vessels from a pre-existing vascular network or dampening excessive blood growth. However, clinical translation of these approaches is slow and challenging. In this review, we discuss recent preclinical approaches to regulate angiogenesis and their potential and risks in a clinical setting.Rust, R., Gantner, C., Schwab, M. E. Pro- and antiangiogenic therapies: current status and clinical implications.

引用

页码：34 / 48

页数：15

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