Pro- and antiangiogenic therapies: current status and clinical implications

被引：62
作者：
Rust, Ruslan [1 ,2 ]
Gantner, Christina [3 ]
Schwab, Martin E. [1 ,2 ]
机构：
[1] Univ Zurich, Brain Res Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland
[2] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Zurich, Switzerland
[3] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Dept Biol, Zurich, Switzerland
来源：
FASEB JOURNAL | 2019年 / 33卷 / 01期
关键词：
vascularization; vascular repair; stroke; retinopathy; cancer; ENDOTHELIAL GROWTH-FACTOR; METASTATIC COLORECTAL-CANCER; CHRONIC MYOCARDIAL-ISCHEMIA; MESENCHYMAL STEM-CELLS; ANTI-VEGF THERAPY; VASCULAR-PERMEABILITY; PROGENITOR CELLS; IN-VITRO; INTRAVITREAL INJECTION; PROMOTES ANGIOGENESIS;
D O I：
10.1096/fj.201800640RR
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Blood vessels nurture every part of the human body. Consequently, abnormalities in the vasculature are closely associated with a variety of diseases, including cerebral stroke, heart disease, retinopathy, and cancer. Pro- or antiangiogenic therapies can influence these diseases by regulating the growth of new blood vessels from a pre-existing vascular network or dampening excessive blood growth. However, clinical translation of these approaches is slow and challenging. In this review, we discuss recent preclinical approaches to regulate angiogenesis and their potential and risks in a clinical setting.Rust, R., Gantner, C., Schwab, M. E. Pro- and antiangiogenic therapies: current status and clinical implications.
引用
收藏
页码：34 / 48
页数：15
相关论文
共 128 条
[1]  
Abcouwer S. F., 2013, J CLIN CELL IMMUN S1, V1, DOI [10.4172/2155-9899, DOI 10.4172/2155-9899]
[2]   INCREASED VASCULAR ENDOTHELIAL GROWTH-FACTOR LEVELS IN THE VITREOUS OF EYES WITH PROLIFERATIVE DIABETIC-RETINOPATHY [J].
ADAMIS, AP ;
MILLER, JW ;
BERNAL, MT ;
DAMICO, DJ ;
FOLKMAN, J ;
YEO, TK ;
YEO, KT .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1994, 118 (04) :445-450
[3]   Axon Guidance Molecules in Vascular Patterning [J].
Adams, Ralf H. ;
Eichmann, Anne .
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (05) :a001875
[4]   VASCULAR ENDOTHELIAL GROWTH-FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC-RETINOPATHY AND OTHER RETINAL DISORDERS [J].
AIELLO, LP ;
AVERY, RL ;
ARRIGG, PG ;
KEYT, BA ;
JAMPEL, HD ;
SHAH, ST ;
PASQUALE, LR ;
THIEME, H ;
IWAMOTO, MA ;
PARK, JE ;
NGUYEN, HV ;
AIELLO, LM ;
FERRARA, N ;
KING, GL .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (22) :1480-1487
[5]   Isolation of putative progenitor endothelial cells for angiogenesis [J].
Asahara, T ;
Murohara, T ;
Sullivan, A ;
Silver, M ;
vanderZee, R ;
Li, T ;
Witzenbichler, B ;
Schatteman, G ;
Isner, JM .
SCIENCE, 1997, 275 (5302) :964-967
[6]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[7]   Modes of resistance to anti-angiogenic therapy [J].
Bergers, Gabriele ;
Hanahan, Douglas .
NATURE REVIEWS CANCER, 2008, 8 (08) :592-603
[8]   Vascular Endothelial Growth Factor Receptor 2 Direct Interaction with Nephrin Links VEGF-A Signals to Actin in Kidney Podocytes [J].
Bertuccio, Claudia ;
Veron, Delma ;
Aggarwal, Pardeep K. ;
Holzman, Lawrence ;
Tufro, Alda .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (46) :39933-39944
[9]   Endothelial progenitor cells correlate with lesion volume and growth in acute stroke [J].
Bogoslovsky, T. ;
Chaudhry, A. ;
Latour, L. ;
Maric, D. ;
Luby, M. ;
Spatz, M. ;
Frank, J. ;
Warach, S. .
NEUROLOGY, 2010, 75 (23) :2059-2062
[10]   MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice [J].
Bonauer, Angelika ;
Carmona, Guillaume ;
Iwasaki, Masayoshi ;
Mione, Marina ;
Koyanagi, Masamichi ;
Fischer, Ariane ;
Burchfield, Jana ;
Fox, Henrik ;
Doebele, Carmen ;
Ohtani, Kisho ;
Chavakis, Emmanouil ;
Potente, Michael ;
Tjwa, Marc ;
Urbich, Carmen ;
Zeiher, Andreas M. ;
Dimmeler, Stefanie .
SCIENCE, 2009, 324 (5935) :1710-1713
12345678910