Immunomodulatory effects of G-CSF in cancer: Therapeutic implications

被引:31
作者
Mouchemore, Kellie A. [1 ,2 ]
Anderson, Robin L. [1 ,2 ,3 ]
机构
[1] Olivia Newton John Canc Res Inst, 145 Studley Rd, Heidelberg, Vic 3084, Australia
[2] La Trobe Univ, Sch Canc Med, Bundoora, Vic 3086, Australia
[3] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia
基金
英国医学研究理事会;
关键词
G-CSF; Cancer; Metastasis; Therapy; Neutrophils; MDSCs; COLONY-STIMULATING FACTOR; REDUCED CLINICAL BENEFIT; TO-LYMPHOCYTE RATIO; ANTI-VEGF THERAPY; DENDRITIC CELLS; LUNG-CANCER; IFN-GAMMA; NK CELL; GRANULOCYTE; NEUTROPHILS;
D O I
10.1016/j.smim.2021.101512
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Numerous preclinical studies have reported a pro-tumour role for granulocyte colony-stimulating factor (G-CSF) that is predominantly mediated by neutrophils and MDSCs, the major G-CSF receptor expressing populations. In the presence of G-CSF (either tumour-derived or exogenous) these myeloid populations commonly exhibit a T cell suppressive phenotype. However, the direct effects of this cytokine on other immune lineages, such as T and NK cells, are not as well established. Herein we discuss the most recent data relating to the effect of G-CSF on the major immune populations, exclusively in the context of cancer. Recent publications have drawn attention to the other tumour-promoting effects of G-CSF on myeloid cells, including NETosis, promotion of cancer stemness and skewed differentiation of bone marrow progenitors towards myelopoiesis. Although G-CSF is safely and commonly used as a supportive therapy to prevent or treat chemotherapy-associated neutropenia in cancer patients, we also discuss the potential impacts of G-CSF on other anti-cancer treatments. Importantly, considerations for immune checkpoint blockade are highlighted, as many publications report a T cell suppressive effect of G-CSF that may diminish the effectiveness of this immunotherapy.
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页数:13
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