MicroRNA Function in the Nervous System

被引：63
作者：
Fiore, Roberto [1 ,2 ]
Khudayberdiev, Sharof [1 ,2 ]
Saba, Reuben [1 ,2 ]
Schratt, Gerhard [1 ,2 ]
机构：
[1] Heidelberg Univ, Interdisziplinares Zentrum Neurowissensch, Jr Grp SFB488, Heidelberg, Germany
[2] Univ Klinikum Heidelberg, Inst Neuroanat, Heidelberg, Germany
来源：
PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE: CELLULAR RNA INTERFERENCE MECHANISMS, VOL 102 | 2011年 / 102卷
关键词：
MU-OPIOID RECEPTOR; MENTAL-RETARDATION PROTEIN; BRAIN-EXPRESSED MICRORNAS; NEURAL CELL SPECIFICATION; POSTTRANSCRIPTIONAL REGULATION; MESSENGER-RNA; SELF-RENEWAL; STEM-CELLS; OLIGODENDROCYTE DIFFERENTIATION; HUNTINGTONS-DISEASE;
D O I：
10.1016/B978-0-12-415795-8.00004-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) are an extensive class of small noncoding RNAs that control posttranscriptional gene expression. miRNAs are highly expressed in neurons where they play key roles during neuronal differentiation, synaptogenesis, and plasticity. It is also becoming increasingly evident that miRNAs have a profound impact on higher cognitive functions and are involved in the etiology of several neurological diseases and disorders. In this chapter, we summarize our current knowledge of miRNA functions during neuronal development, physiology, and dysfunction.
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页码：47 / 100
页数：54
相关论文
共 163 条
[1]   Sequence variants in SLITRK1 are associated with Tourette's syndrome [J].
Abelson, JF ;
Kwan, KY ;
O'Roak, BJ ;
Baek, DY ;
Stillman, AA ;
Morgan, TM ;
Mathews, CA ;
Pauls, DA ;
Rasin, MR ;
Gunel, M ;
Davis, NR ;
Ercan-Sencicek, AG ;
Guez, DH ;
Spertus, JA ;
Leckman, JF ;
Dure, LS ;
Kurlan, R ;
Singer, HS ;
Gilbert, DL ;
Farhi, A ;
Louvi, A ;
Lifton, RP ;
Sestan, N ;
State, MW .
SCIENCE, 2005, 310 (5746) :317-320
[2]   Heterogeneous dysregulation of microRNAs across the autism spectrum [J].
Abu-Elneel, Kawther ;
Liu, Tsunglin ;
Gazzaniga, Francesca S. ;
Nishimura, Yuhei ;
Wall, Dennis P. ;
Geschwind, Daniel H. ;
Lao, Kaiqin ;
Kosik, Kenneth S. .
NEUROGENETICS, 2008, 9 (03) :153-161
[3]   MicroRNA-338 Regulates Local Cytochrome c Oxidase IV mRNA Levels and Oxidative Phosphorylation in the Axons of Sympathetic Neurons [J].
Aschrafi, Armaz ;
Schwechter, Azik D. ;
Mameza, Marie G. ;
Natera-Naranjo, Orlangie ;
Gioio, Anthony E. ;
Kaplan, Barry B. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (47) :12581-12590
[4]   Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila [J].
Ashraf, SI ;
McLoon, AL ;
Sclarsic, SM ;
Kunes, S .
CELL, 2006, 124 (01) :191-205
[5]   Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs [J].
Babiarz, Joshua E. ;
Ruby, J. Graham ;
Wang, Yangming ;
Bartel, David P. ;
Blelloch, Robert .
GENES & DEVELOPMENT, 2008, 22 (20) :2773-2785
[6]   A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation [J].
Banerjee, Sourav ;
Neveu, Pierre ;
Kosik, Kenneth S. .
NEURON, 2009, 64 (06) :871-884
[7]   Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies [J].
Barbee, Scott A. ;
Estes, Patricia S. ;
Cziko, Anne-Marie ;
Hillebrand, Jens ;
Luedeman, Rene A. ;
Coller, Jeff M. ;
Johnson, Nick ;
Howlett, Iris C. ;
Geng, Cuiyun ;
Ueda, Ryu ;
Brand, Andrea H. ;
Newbury, Sarah F. ;
Wilhelm, James E. ;
Levine, Richard B. ;
Nakamura, Akira ;
Parker, Roy ;
Ramaswami, Mani .
NEURON, 2006, 52 (06) :997-1009
[8]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[9]   MicroRNA Processing Pathway Regulates Olfactory Neuron Morphogenesis [J].
Berdnik, Daniela ;
Fan, Audrey P. ;
Potter, Christopher J. ;
Luo, Liquin .
CURRENT BIOLOGY, 2008, 18 (22) :1754-1759
[10]   Dicer is essential for mouse development [J].
Bernstein, E ;
Kim, SY ;
Carmell, MA ;
Murchison, EP ;
Alcorn, H ;
Li, MZ ;
Mills, AA ;
Elledge, SJ ;
Anderson, KV ;
Hannon, GJ .
NATURE GENETICS, 2003, 35 (03) :215-217
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