Trends in Exposure to Polyfluoroalkyl Chemicals in the US Population: 1999-2008

被引：628
作者：
Kato, Kayoko [1 ]
Wong, Lee-Yang [1 ]
Jia, Lily T. [1 ]
Kuklenyik, Zsuzsanna [1 ]
Calafat, Antonia M. [1 ]
机构：
[1] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA
来源：
ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2011年 / 45卷 / 19期
关键词：
PERFLUORINATED COMPOUNDS; SERUM CONCENTRATIONS; NATIONAL-HEALTH; TIME TRENDS;
D O I：
10.1021/es1043613
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Since 2002, practices in manufacturing polyfluoroalkyl chemicals (PFCs) in the United States have changed. Previous results from the National Health and Nutrition Examination Survey (NHANES) documented a significant decrease in serum concentrations of some PFCs during 1999-2004. To further assess concentration trends of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA), we analyzed 7876 serum samples collected from a representative sample of the general U.S. population >= 12 years of age during NHANES 1999-2008. We detected PFOS, PFOA, PFNA, and PFHxS in more than 95% of participants. Concentrations differed by sex regardless of age and we observed some differences by race/ethnicity. Since 1999-2000, PFOS concentrations showed a significant downward trend, because of discontinuing industrial production of PFOS, but PFNA concentrations showed a significant upward trend. PFOA concentrations during 1999-2000 were significantly higher than during any other time period examined, but PFOA concentrations have remained essentially unchanged during 2003-2008. PFHxS concentrations showed a downward trend from 1999 to 2006, but concentrations increased during 2007-2008. Additional research is needed to identify the environmental sources contributing to human exposure to PFCs. Nonetheless, these NHANES data suggest that sociodemographic factors may influence exposure and also provide unique information on temporal trends of exposure.
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收藏
页码：8037 / 8045
页数：9
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