Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2

被引：68
作者：
Tian, Yuanyuan [1 ]
Song, Wei [1 ]
Xu, Dongsheng [1 ]
Chen, Xiao [1 ]
Li, Xiaojiao [2 ]
Zhao, Yuguang [1 ,2 ]
机构：
[1] First Hosp Jilin Univ, Canc Ctr, Changchun 130021, Jilin, Peoples R China
[2] First Hosp Jilin Univ, Phase Clin Trials Unit 1, Changchun 130021, Jilin, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020年 / 2020卷
基金：
美国国家科学基金会;
关键词：
TRANSCRIPTION FACTOR NRF2; MALE REPRODUCTIVE-TRACT; GLYCATION END-PRODUCTS; HUMAN-SPERMATOZOA; SPERM FUNCTION; INDUCED HYPERGLYCEMIA; TESTICULAR APOPTOSIS; LIPID-PEROXIDATION; REDOX REGULATION; SERTOLI-CELLS;
D O I：
10.1155/2020/7156579
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Testicular dysfunction due to hyperglycemia is the main cause of infertility in diabetic men. Over the years, in order to solve this growing problem, a lot of research has been done and a variety of treatments have been created, but so far, there is no safe, effective, and practical method to prevent male infertility caused by diabetes. In this review, we emphasize the male infertility mechanism caused by diabetes from the effects of oxidative stress and autophagy on the function of testes via the PI3K/Akt/mTOR signaling pathway, and we highlight that oxidative stress-induced autophagy breaks the feedforward loop linking Nrf2 and p62 and promotes oxidative damage in diabetic testes.
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页数：9
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