Hepatic Encephalopathy: Current and Emerging Treatment Modalities

被引：27

作者：

Fallahzadeh, Mohammad Amin ^{[1
]}

Rahimi, Robert S. ^{[1
]}

机构：

[1] Baylor Univ, Med Ctr, Baylor Scott & White Hlth, Dallas, TX 75246 USA

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2022年 / 20卷 / 08期

关键词：

Altered Mental Status; Ammonia; Chronic Liver Disease; Cirrhosis; Pharmacologic Therapy; CHAIN AMINO-ACIDS; PROTON PUMP INHIBITORS; GUT MICROBIOTA; DOUBLE-BLIND; ORNITHINE PHENYLACETATE; GLYCEROL PHENYLBUTYRATE; NITROGEN-METABOLISM; ALBUMIN DIALYSIS; CIRRHOSIS; AMMONIA;

D O I：

10.1016/j.cgh.2022.04.034

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatic encephalopathy (HE) is a potentially reversible neurocognitive complication of cirrhosis. It has been reported in at least 30% of patients with cirrhosis and imposes a significant economic burden on caregivers and the healthcare system. Ammonia has been recognized as the culprit in HE development, and all the currently approved treatments mostly act on this toxin to help with HE resolution. After a brief overview of HE characteristics and pathophysiology, this review explores the current accepted treatments for this debilitating complication of cirrhosis. This is followed by an overview of the novel available therapies and a brief focus on future treatment modalities for HE.

引用

页码：S9 / S19

页数：11

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