Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells

被引：8

作者：

Chen, Jibing ^{[1
,2
]}

Yang, Wei ^{[1
]}

Yu, Chunlei ^{[1
]}

Li, Yi ^{[1
]}

机构：

[1] Jilin Univ, Norman Bethune Med Coll, Dept Immunol, Changchun, Peoples R China

[2] Xiamen Univ, Coll Med, Basic Med Dept, Xia Men, Peoples R China

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2008年 / 37卷 / 03期

关键词：

autoimmune regulator; promiscuous genes expression; TECs; tissue-restricted antigens;

D O I：

10.1080/08820130801967841

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmune (non-obese diabetic [NOD]) mouse model express much lower levels of an autoimmune regulator (Aire) and TRAs than normal (Balb/c) TECs. Transfection of an Aire plasmid led to increased levels of TRA expression in cultured TECs from Balb/c and NOD mice; an increase that was enhanced by the presence of thymocytes. These data show that Aire initiates promiscuous gene expression in TECs, and that this function might be under thymocyte control.

引用

页码：203 / 214

页数：12

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