A Computational Study of Microscale Flow and Mass Transport in Vasculatized Tumors

被引：0

作者：

Nabil, Mahdi ^{[1
]}

Zunino, Paolo ^{[1
]}

Cattaneo, Laura ^{[2
]}

机构：

[1] Univ Pittsburgh, Dept Mech Engn & Mat Sci, Pittsburgh, PA 15260 USA

[2] Politecn Milan, Dept Math, Milan, Italy

来源：

2014 21th Iranian Conference on Biomedical Engineering (ICBME) | 2014年

关键词：

perfusion and mass transport; microvascular environment; drug delivery; MODELS; FLUID;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We develop A computational finite element model to study microcirculation and drug delivery to tumors under drug bolus injection into the blood stream. The mathematical model is based on the fundamental laws of filtration and transport in biological tissues at the micro-scale level. The model consists of two separate regions. A network of vessels carrying blood flow (the capillaries), and the surrounding tissue (interstitial volume). A comparison of flow and mass transport in healthy and tumor tissue models is presented using four case studies with different physiological properties.

引用

页码：23 / 28

页数：6

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