Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus

被引：31

作者：

Abdissa, Negera ^{[1
,2
]}

Frese, Marcel ^{[1
]}

Sewald, Norbert ^{[1
]}

机构：

[1] Bielefeld Univ, Dept Chem Organ & Bioorgan Chem, POB 100131, D-33501 Bielefeld, Germany

[2] Jimma Univ, Dept Chem, Coll Nat Sci, POB 378, Jimma 251, Ethiopia

来源：

MOLECULES | 2017年 / 22卷 / 11期

关键词：

antibiotic; benzoquinone; ethnomedicine; diterpenoids; plant-derived natural products; ROOT;

D O I：

10.3390/molecules22111919

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new para-benzoquinone containing abietane-type diterpenoids (1-4) along with thirteen known diterpenoids (5-17) were isolated from the roots of Plectranthus punctatus. The structures of the compounds were established by detailed spectroscopic analyses and comparison with literature data. The compounds were tested for their antibacterial and cytotoxic activity and showed significant inhibitory activity against all bacterial strains used, with compounds 6, 8, 10, and 11 showing an inhibition zone for Staphylococcus warneri even greater than the reference drug, gentamycin.

引用

页数：11

共 26 条

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