Adipose tissue biology and HIV-infection

被引：56
作者：
Giralt, Marta [1 ,2 ,3 ]
Domingo, Pere [4 ,5 ]
Villarroya, Francesc [2 ,3 ]
机构：
[1] Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, E-08028 Barcelona, Catalonia, Spain
[2] Univ Barcelona, Inst Biomed IBUB, E-08028 Barcelona, Catalonia, Spain
[3] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Barcelona, Spain
[4] Hosp Santa Creu & Sant Pau, Infect Dis Unit, Barcelona, Catalonia, Spain
[5] Inst Salud Carlos III, Red Invest SIDA RIS, Barcelona, Spain
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2011年 / 25卷 / 03期
关键词：
adipose; adipokine; adipocyte; HIV-1; lipodystrophy; antiretroviral; REVERSE-TRANSCRIPTASE INHIBITORS; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; ANTIRETROVIRAL-THERAPY; GENE-EXPRESSION; ADIPOCYTE DIFFERENTIATION; PROTEASE INHIBITORS; IN-VITRO; HIV-1-INFECTED PATIENTS; FAT REDISTRIBUTION;
D O I：
10.1016/j.beem.2010.12.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
HIV-1/highly active antiretroviral therapy-associated lipodystrophy syndrome (HALS) is an adipose tissue redistribution disorder characterized by subcutaneous adipose tissue lipoatrophy, sometimes including visceral adipose tissue hypertrophy and accumulation of dorsocervical fat ('buffalo hump'). The pathophysiology of HALS appears to be multifactorial and several key pathophysiological factors associated with HALS have been identified. These include mitochondrial dysfunction, adipocyte differentiation disturbances, high adipocyte lipolysis, and adipocyte apoptosis. These alterations in adipose tissue biology expand to involve systemic metabolism through alterations in endocrine functions of adipose tissue (via disturbed adipokine release), enhanced production of pro-inflammatory cytokines and excessive free fatty-acid release due to lipolysis. The deleterious action of some antiretroviral drugs is an important factor in eliciting these alterations in adipose tissue. However, HIV-1 infection-related events and HIV-1-encoded proteins also contribute directly to the complex development of HALS through effects on adipocyte biology, or indirectly through the promotion of local inflammation in adipose tissue. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：487 / 499
页数：13
相关论文
共 93 条
[71]   The HIV protease inhibitor nelfinavir induces insulin resistance and increases basal lipolysis in 3T3-L1 adipocytes [J].
Rudich, A ;
Vanounou, S ;
Riesenberg, K ;
Porat, M ;
Tirosh, A ;
Harman-Boehm, I ;
Greenberg, AS ;
Schlaeffer, F ;
Bashan, N .
DIABETES, 2001, 50 (06) :1425-1431
[72]   Prevalence of metabolic syndrome in HIV-infected patients receiving highly active antiretroviral therapy using International Diabetes Foundation and Adult Treatment Panel III criteria - Associations with insulin resistance, disturbed body fat compartmentalization, elevated C-reactive peptide, and hypoadiponectinemia [J].
Samaras, Katherine ;
Wand, Handan ;
Law, Matthew ;
Emery, Sean ;
Cooper, David ;
Carr, Andrew .
DIABETES CARE, 2007, 30 (01) :113-119
[73]   Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy [J].
Sevastianova, Ksenia ;
Sutinen, Jussi ;
Kannisto, Katja ;
Hamsten, Anders ;
Ristola, Matti ;
Yki-Jarvinen, Hannele .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 295 (01) :E85-E91
[74]   Clinical aspects of endothelial dysfunction associated with human immunodeficiency virus infection and antiretroviral agents [J].
Shankar S.S. ;
Dubé M.P. .
Cardiovascular Toxicology, 2004, 4 (3) :261-269
[75]   Gene Expression and Immunohistochemistry in Adipose Tissue of HIV Type 1-Infected Patients with Nucleoside Analogue Reverse-Transcriptase Inhibitor-Associated Lipoatrophy [J].
Sievers, M. ;
Walker, U. A. ;
Sevastianova, K. ;
Setzer, B. ;
Wagsater, D. ;
Eriksson, P. ;
Yki-Jarvinen, H. ;
Sutinen, J. .
JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (02) :252-262
[76]   Zidovudine impairs adipogenic differentiation through inhibition of clonal expansion [J].
Stankov, Metodi V. ;
Schmidt, Reinhold E. ;
Behrens, Georg M. N. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (08) :2882-2889
[77]   Mitochondrial DNA Depletion and Respiratory Chain Activity in Primary Human Subcutaneous Adipocytes Treated with Nucleoside Analogue Reverse Transcriptase Inhibitors [J].
Stankov, Metodi V. ;
Luecke, Thomas ;
Das, Anibh M. ;
Schmidt, Reinhold E. ;
Behrens, Georg M. N. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (01) :280-287
[78]   A paracrine loop between adipocytes and macrophages aggravates inflammatory changes -: Role of free fatty acids and tumor necrosis factor α [J].
Suganami, T ;
Nishida, J ;
Ogawa, Y .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (10) :2062-2068
[79]   Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with active antiretroviral therapy-associated lipodystrophy [J].
Sutinen, J ;
Korsheninnikova, E ;
Funahashi, T ;
Matsuzawa, Y ;
Nyman, T ;
Yki-Järvinen, H .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (04) :1907-1910
[80]   The role of adipokines in relation to HIV lipodystrophy [J].
Sweeney, Laura L. ;
Brennan, Aoife M. ;
Mantzoros, Christos S. .
AIDS, 2007, 21 (08) :895-904
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