Hairy Root Extract of Angelica gigas Exerts Anticancer Activity towards Human Ovarian Cancer

被引：0
作者：
Liu, Aihua [1 ]
Liu, Mengna [2 ]
Meng, Xiaoyan [3 ]
Lu, Meirong [4 ]
Han, Jiangqiong [5 ]
机构：
[1] Penglai Peoples Hosp, Dept Obstet, Yantai 265600, Shandong, Peoples R China
[2] Xuzhou Cent Hosp, Dept Obstet & Gynecol, Xuzhou 221000, Jiangsu, Peoples R China
[3] Wuzhong Peoples Hosp Suzhou City, Dept Obstet & Gynecol, Suzhou 215128, Jiangsu, Peoples R China
[4] Xian Int Med Ctr Hosp, Gynecol Dept, Xian 710010, Shaanxi, Peoples R China
[5] Kunming Med Univ, Yunnan Canc Ctr, Affiliated Hosp 3, Yunnan Canc Hosp,Dept Integrated Tradit Chinese &, Kunming 650118, Yunnan, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2021年 / 40卷 / 11期
关键词：
apoptosis; Bcl2; cytotoxicity; extract; invasion; migration; NATURAL-PRODUCTS; DRUGS; APOPTOSIS; DECURSIN; CELLS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the present study, we wish to evaluate the anticancer properties of hairy root extract of Angelica gigas Nakai (hAGE) against ovarian cancer. Initially, the cytotoxicity of hAGE was determined against human ovarian cancer cells (A2780, OVCAR-3 and SKOV-3 cells) and human normal ovarian surface epithelial cell (OSE), where they potently inhibit SKOV-3 cells as compared to other cells, with no toxicity to normal cell. In hAGE also causes significant inhibition of migration and invasion of SKOV-3 cells in dose-dependent manner. It also showed inhibition of apoptosis in SKOV-3 cell in dose-dependent manner in annexin V propidium iodide assay. In western blotting, hAGE cause significant decrease in Bcl-2 levels and increase in Bax levels as compared to the control cells. Collectively, our study demonstrated strong anti-ovarian cancer effect of hAGE by induction of apoptosis and inhibition of migration and invasion of ovarian cancer cells. The present study reveals that hAGE may offer a valuable option for the treatment of ovarian cancer.
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页码：2628 / 2634
页数：7
相关论文
共 33 条
[1]   The Role of Cancer Stem Cells and Mechanical Forces in Ovarian Cancer Metastasis [J].
Bregenzer, Michael E. ;
Horst, Eric N. ;
Mehta, Pooja ;
Novak, Caymen M. ;
Repetto, Taylor ;
Mehta, Geeta .
CANCERS, 2019, 11 (07)
[2]   Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression [J].
Cho, Joon Hyeong ;
Kwon, Jung Eun ;
Cho, Youngmi ;
Kim, Inhye ;
Kang, Se Chan .
NUTRIENTS, 2015, 7 (06) :4862-4874
[3]  
Dai H., 2016, Cancer Transl. Med, V2, P7, DOI [10.4103/2395-3977.177558, DOI 10.4103/2395-3977.177558]
[4]   Association between tumor mutation burden and immune infiltration in ovarian cancer [J].
Fan, Suzhen ;
Gao, Xiang ;
Qin, Qiaohong ;
Li, Hongyu ;
Yuan, Zhongfu ;
Zhao, Shujun .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 89
[5]   Sustained proliferation in cancer: Mechanisms and novel therapeutic targets [J].
Feitelson, Mark A. ;
Arzumanyan, Alla ;
Kulathinal, Rob J. ;
Blain, Stacy W. ;
Holcombe, Randall F. ;
Mahajna, Jamal ;
Marino, Maria ;
Martinez-Chantar, Maria L. ;
Nawroth, Roman ;
Sanchez-Garcia, Isidro ;
Sharma, Dipali ;
Saxena, Neeraj K. ;
Singh, Neetu ;
Vlachostergios, Panagiotis J. ;
Guo, Shanchun ;
Honoki, Kanya ;
Fujii, Hiromasa ;
Georgakilas, Alexandros G. ;
Bilsland, Alan ;
Amedei, Amedeo ;
Niccolai, Elena ;
Amin, Amr ;
Ashraf, S. Salman ;
Boosani, Chandra S. ;
Guha, Gunjan ;
Ciriolo, Maria Rosa ;
Aquilano, Katia ;
Chen, Sophie ;
Mohammed, Sulma I. ;
Azmi, Asfar S. ;
Bhakta, Dipita ;
Halicka, Dorota ;
Keith, W. Nicol ;
Nowsheen, Somaira .
SEMINARS IN CANCER BIOLOGY, 2015, 35 :S25-S54
[6]   RETRACTED: Apoptosis and Molecular Targeting Therapy in Cancer (Retracted Article) [J].
Hassan, Mohamed ;
Watari, Hidemichi ;
AbuAlmaaty, Ali ;
Ohba, Yusuke ;
Sakuragi, Noriaki .
BIOMED RESEARCH INTERNATIONAL, 2014, 2014
[7]   Ovarian Cancer, the Revised FIGO Staging System, and the Role of Imaging [J].
Javadi, Sanaz ;
Ganeshan, Dhakshina M. ;
Qayyum, Aliya ;
Iyer, Revathy B. ;
Bhosale, Priya .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2016, 206 (06) :1351-1360
[8]   Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells [J].
Jiang, Cheng ;
Guo, Junming ;
Wang, Zhe ;
Xiao, Bingxiu ;
Lee, Hyo-Jung ;
Lee, Eun-Ok ;
Kim, Sung-Hoon ;
Lu, Junxuan .
BREAST CANCER RESEARCH, 2007, 9 (06)
[9]   Enhanced intracellular uptake and stability of umbelliferone in compound mixtures from Angelica gigas in vitro [J].
Kang, Yoon Young ;
Kim, Jun Yeong ;
Song, Jihyeon ;
Mok, Hyejung .
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2019, 140 (01) :8-13
[10]   Synergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii and Angelica gigas [J].
Kim, Eun-Young ;
Rhyu, Mee-Ra .
JOURNAL OF ETHNOPHARMACOLOGY, 2010, 130 (03) :545-551
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