Regeneration of pancreatic beta cells

被引：13

作者：

Jun, Hee-Sook ^{[1
]}

机构：

[1] Gachon Univ Med & Sci, Lee Gil Ya Canc & Diabetes Inst, Yeonsu Ku, Inchon 406840, South Korea

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷

关键词：

diabetes; beta cell regeneration; embryonic stem cell; adult stem cell; progenitor cell; pancreatic islet; differentiation; review;

D O I：

10.2741/3145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes mellitus results from inadequate mass of insulin-producing pancreatic beta cells. Type 1 diabetes is characterized by absolute loss of beta cells due to autoimmune-mediated destruction. Type 2 diabetes is characterized by relative deficiency of beta cells due to lack of compensation for insulin resistance. Restoration of deficient beta cell mass by transplantation from exogenous sources or by endogenous regeneration of insulin-producing cells would be therapeutic options. Mature beta cells have an ability to proliferate; however, it has been shown to be difficult to expand adult beta cells in vitro. Alternatively, regeneration of beta cells from embryonic and adult stem cells and pancreatic progenitor cells is an attractive method to restore islet cell mass. With information obtained from the biology of pancreatic development, direct differentiation of stem and progenitor cells toward a pancreatic beta cell phenotype has been tried using various strategies, including forced expression of beta cell-specific transcription factors. Further research is required to understand how endogenous beta cells differentiate and to develop methods to regenerate beta cells for clinically applicable therapies for diabetes.

引用

页码：6170 / 6182

页数：13

共 151 条

[11] Are there pancreatic progenitor cells from which new islets form after birth? [J].

Bonner-Weir, S ;

Sharma, A .

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2006, 2 (05) :240-241

[12] In vitro cultivation of human islets from expanded ductal tissue [J].

Bonner-Weir, S ;

Taneja, M ;

Weir, GC ;

Tatarkiewicz, K ;

Song, KH ;

Sharma, A ;

O'Neil, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :7999-8004

[13] Pancreatic stem cells [J].

Bonner-Weir, S ;

Sharma, A .

JOURNAL OF PATHOLOGY, 2002, 197 (04) :519-526

[14] A 2ND PATHWAY FOR REGENERATION OF ADULT EXOCRINE AND ENDOCRINE PANCREAS - A POSSIBLE RECAPITULATION OF EMBRYONIC-DEVELOPMENT [J].

BONNERWEIR, S ;

BAXTER, LA ;

SCHUPPIN, GT ;

SMITH, FE .

DIABETES, 1993, 42 (12) :1715-1720

[15] Pharmacological treatment of chronic diabetes by stimulating pancreatic β-cell regeneration with systemic co-administration of EGF and gastrin [J].

Brand, SJ ;

Tagerud, S ;

Lambert, P ;

Magill, SG ;

Tatarkiewicz, K ;

Doiron, K ;

Yan, YH .

PHARMACOLOGY & TOXICOLOGY, 2002, 91 (06) :414-420

[16] All β cells contribute equally to islet growth and maintenance [J].

Brennand, Kristen ;

Huangfu, Danwei ;

Melton, Doug .

PLOS BIOLOGY, 2007, 5 (07) :1520-1529

[17] Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing β-cell-like cells [J].

Brolén, GKC ;

Heins, N ;

Edsbagge, J ;

Semb, H .

DIABETES, 2005, 54 (10) :2867-2874

[18] The in vitro differentiation of rat neural stem cells into an insulin-expressing phenotype [J].

Burns, CJ ;

Minger, SL ;

Hall, S ;

Milne, H ;

Ramracheya, RD ;

Evans, ND ;

Persaud, SJ ;

Jones, PM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 326 (03) :570-577

[19] β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes [J].

Butler, AE ;

Janson, J ;

Bonner-Weir, S ;

Ritzel, R ;

Rizza, RA ;

Butler, PC .

DIABETES, 2003, 52 (01) :102-110

[20] High glucose is necessary for complete maturation of Pdx1-VP16 - Expressing hepatic cells into functional insulin-producing cells [J].

Cao, LZ ;

Tang, DQ ;

Horb, ME ;

Li, SW ;

Yang, LJ .

DIABETES, 2004, 53 (12) :3168-3178

← 1 2 3 4 5 6 7 8 9 10 →