THE PROTECTIVE EFFECT OF CURCUMIN AGAINST SODIUM FLUORIDE-INDUCED OXIDATIVE STRESS IN RAT HEART

被引：14

作者：

Nabavi, S. F. ^{[1
]}

Nabavi, S. M. ^{[1
,2
]}

Ebrahimzadeh, M. A. ^{[3
]}

Eslami, Sh. ^{[3
]}

Jafari, N. ^{[2
]}

Hajizadeh Moghaddam, Akbar ^{[2
]}

机构：

[1] Irans Natl Elites Fdn, Tehran 14174, Iran

[2] Univ Mazandaran, Dept Biol, Babol Sar 4741695447, Iran

[3] Mazandaran Univ Med Sci, Dept Med Chem, Fac Pharm, Sari 481751665, Iran

来源：

ARCHIVES OF BIOLOGICAL SCIENCES | 2011年 / 63卷 / 03期

关键词：

Curcumin; oxidative stress; sodium fluoride; enzymatic antioxidant; LIPID-PEROXIDATION; VITAMIN-E; ANTIOXIDANT SYSTEMS; CHRONIC FLUOROSIS; TOXICITY; 2ND-GENERATION; ERYTHROCYTES; INTOXICATION; ENZYMES; TISSUES;

D O I：

10.2298/ABS1103563N

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the present study the cardioprotective effects of curcumin, a herbal polyphenolic compound, against sodium fluoride (NaF)-induced toxicity in rat heart was evaluated. Fifty rats were divided into five experimental groups containing 10 rats each. Group I received standard water and diet and was used as a normal group; groups II and III were pretreated with curcumin intraperitoneally for 7 days prior to NaF intoxication. Group IV was pretreated with vitamin C, a standard antioxidant, intraperitoneally for 7 days prior to NaF intoxication and used as a positive control group. The animals in group V were intoxicated with NaF for the same time and used as a control group. There was a significant increase in lipid peroxidation along with a decrease in superoxide dismutase activity in the homogenates of tissues of the NaF-treated animals. Curcumin pretreatment in animals prior to fluoride intoxication normalized the levels of biochemical parameters measured.

引用

页码：563 / 569

页数：7

共 37 条

[1] The effects of organophosphate insecticide methidathion on lipid peroxidation and anti-oxidant enzymes in rat erythrocytes: role of vitamins E and C [J].