Taccasubosides A-D, four new steroidal glycosides from Tacca subflabellata

被引：15

作者：

Li, Lei ^{[1
,2
]}

Ni, Wei ^{[1
]}

Li, Xing-Rao ^{[1
]}

Hua, Yan ^{[2
]}

Fang, Ping-Lei ^{[1
]}

Kong, Ling-Mei ^{[1
]}

Pan, Li-Li ^{[1
]}

Li, Yan ^{[1
]}

Chen, Chang-Xiang ^{[1
]}

Liu, Hai-Yang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] SW Forestry Univ, Fac Nat Resources, Kunming 650224, Peoples R China

来源：

STEROIDS | 2011年 / 76卷 / 10-11期

关键词：

Tacca subflabellata; Taccaceae; Taccasubosides A-D; Cytotoxic activity; SPIROSTANOL SAPONINS; PENTACYCLIC STEROIDS; TACCALONOLIDE-A; RHIZOMES; CHANTRIERI; GLUCOSIDES; ROOTS;

D O I：

10.1016/j.steroids.2011.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By analyzing the steroidal content of fresh whole plants of Tacca subflabellata (Taccaceae), we isolated one sapogenin and eight glycosides with four kinds of steroidal skeletons including four new glycosides, named taccasubosides A-D (1-4), together with five known compounds. Among them, compound 1 is the first pentacyclic sterol glycoside with 6-6-6-5-6 fused rings. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analysis, including that of 2D NMR data, and the results of acidic hydrolysis. The cytotoxicity of the selected steroidal glycosides (1-4, 8, and 9) was evaluated in vitro against five human cancer cell lines. Compound 9 showed significant inhibitory activity against all five cell lines. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1037 / 1042

页数：6

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