Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak

被引：5
|
作者：
Zhang, Ju [1 ,2 ]
Ding, Nan [1 ,2 ]
Song, Yangzi [1 ,2 ]
Song, Rui [1 ]
Pan, Yang [3 ]
Wang, Linghang [1 ,2 ]
Yan, Shuo [1 ]
Wang, Qi [1 ]
Ma, Shanfang [1 ]
Wei, Lirong [1 ]
Yu, Fengting [1 ,2 ]
Lu, Lianhe [1 ]
Zhang, Fujie [1 ,2 ]
Chen, Chen [1 ,2 ]
Zeng, Hui [1 ,2 ]
机构：
[1] Capital Med Univ, Beijing Ditan Hosp, Beijing 100015, Peoples R China
[2] Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China
[3] Beijing Ctr Dis Prevent & Control, Inst Infect Dis & Endem Dis Control, Beijing 100013, Peoples R China
来源：
INNOVATION | 2021年 / 2卷 / 02期
基金：
中国国家自然科学基金;
关键词：
SARS-CoV-2; COVID-19; asymptomatic transmission; outbreak; phylogenomic; CORONAVIRUS; ALIGNMENT; CHINA;
D O I：
10.1016/j.xinn.2021.100099
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles' heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.
引用
收藏
页数：7
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