A Chemoenzymatic Cascade Combining a Hydration Catalyst with an Amine Dehydrogenase: Synthesis of Chiral Amines

被引：28

作者：

Chang, Fengwei ^{[1
]}

Wang, Chengyi ^{[1
]}

Chen, Qipeng ^{[1
]}

Zhang, Yongjin ^{[1
]}

Liu, Guohua ^{[1
]}

机构：

[1] Shanghai Normal Univ, Int Joint Lab Resource Chem & Engn Res Ctr Green, Shanghai 200234, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 10期

关键词：

amine dehydrogenase; asymmetric catalysis; hydration; mesoporous materials; reductive amination; ASYMMETRIC-SYNTHESIS; REDUCTIVE AMINATION; PIVOTAL ROLE; COMPLEXES; ALCOHOLS;

D O I：

10.1002/anie.202114809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combination of biocatalysis and transition-metal catalysis can complement synthetic gaps only in a chemical or biological process. However, the intrinsic mutual deactivation between enzymatic and chemical species is a significant challenge in a single operation. To address the above issue, we developed an encapsulated Au/carbene combined with a free amine dehydrogenase as a co-catalyst system that enables an efficient hydration/amination enantioselective cascade process to be accomplished. The mechanistic investigation discloses dual catalysis comprised of alkyne hydration, followed by a reductive amination process.

引用

页数：5

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