Inhibitory Effect of Acai (Euterpe oleracea Mart.) Pulp on IgE-Mediated Mast Cell Activation

被引：11
|
作者：
Horiguchi, Tomoko [1 ]
Ishiguro, Nahoko [1 ]
Chihara, Kazuyasu [2 ]
Ogi, Kazuhiro [2 ]
Nakashima, Kenji [2 ]
Sada, Kiyonao [2 ]
Hori-Tamura, Naoko [1 ]
机构：
[1] Kobe Womens Univ, Biochem Lab, Grad Sch Life Sci, Kobe, Hyogo 6548585, Japan
[2] Univ Fukui, Div Microbiol, Dept Pathol Sci, Fac Med Sci, Fukui 910, Japan
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 10期
基金：
日本学术振兴会;
关键词：
mast cells; signal transduction; protein tyrosine kinase; acai; Euterpe oleracea Mart; FC-EPSILON-RI; PROTEIN-TYROSINE KINASE; LEUKEMIA RBL-2H3 CELLS; HIGH-AFFINITY; NEGATIVE REGULATION; IMMUNOGLOBULIN-E; DEFICIENT MICE; SH2; DOMAIN; RECEPTOR; SYK;
D O I：
10.1021/jf2005707
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The palm fruit acai is known to have potential health benefits due to its antioxidant scavenging capacities. Pretreatment of IgE-sensitized mouse primary cultured mast cells with acai pulp resulted in the dramatic suppression of antigen-induced degranulation in a dose-dependent manner. Similarly, acai suppressed IgE-mediated degranulation and transcription of the cytokine genes from a cultured mast cell line of rat basophilic leukemia (RBL)-2H3 cells. Acai could selectively inhibit Fc epsilon RI signaling pathways. Furthermore, the Fc epsilon RI-mediated complementary signaling pathway was also suppressed by acai. These results demonstrate that acai is a potent inhibitor of IgE-mediated mast cell activation.
引用
收藏
页码：5595 / 5601
页数：7
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