Mutated β-catenin evades a microRNA-dependent regulatory loop

被引：54

作者：

Veronese, Angelo ^{[1
,2
]}

Visone, Rosa ^{[2
]}

Consiglio, Jessica ^{[2
]}

Acunzo, Mario ^{[2
]}

Lupini, Laura ^{[1
]}

Kim, Taewan ^{[2
]}

Ferracin, Manuela ^{[1
]}

Lovat, Francesca ^{[2
]}

Miotto, Elena ^{[1
]}

Balatti, Veronica ^{[2
]}

D'Abundo, Lucilla ^{[1
]}

Gramantieri, Laura ^{[3
]}

Bolondi, Luigi ^{[3
]}

Pekarsky, Yuri ^{[2
]}

Perrotti, Danilo ^{[2
]}

Negrini, Massimo ^{[1
]}

Croce, Carlo M. ^{[1
,2
]}

机构：

[1] Univ Ferrara, Dipartimento Med Sperimentale & Diagnost, I-44100 Ferrara, Italy

[2] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[3] Univ Bologna, Dipartimento Med Interna & Gastroenterol, I-40138 Bologna, Italy

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2011年 / 108卷 / 12期

关键词：

HUMAN HEPATOCELLULAR CARCINOMAS; UPSTREAM STIMULATORY FACTOR; BECKWITH-WIEDEMANN-SYNDROME; WILMS-TUMOR; TARGET SITES; CTCF BINDING; COLON-CANCER; STEM-CELLS; GENE; EXPRESSION;

D O I：

10.1073/pnas.1101734108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

hsa-mir-483 is located within intron 2 of the IGF2 gene. We have previously shown oncogenic features of miR-483-3p through cooperation with IGF2 or by independently targeting the proapoptotic gene BBC3/PUMA. Here we demonstrate that expression of miR-483 can be induced independently of IGF2 by the oncoprotein beta-catenin through an interaction with the basic helix-loop-helix protein upstream stimulatory transcription factor 1. We also show that beta-catenin itself is a target of miR-483-3p, triggering a negative regulatory loop that becomes ineffective in cells harboring an activating mutation of beta-catenin. These results provide insights into the complex regulation of the IGF2/miR-483 locus, revealing players in the beta-catenin pathway.

引用

页码：4840 / 4845

页数：6

共 43 条

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