Alterations in protein kinase A signalling and cleft palate: a review

被引:5
作者
Reddy, CS [1 ]
机构
[1] Univ Missouri, Coll Vet Med, Dept Biomed Sci, Columbia, MO 65211 USA
关键词
cleft palate; cyclic AMP; protein kinase A; secalonic acid D;
D O I
10.1191/0960327105ht514oa
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Cyclic AMP is an important second messenger mediating the actions of many hormones and other ligands in a variety of cells. Cells of the developing organism are no exception. Once generated, it releases the catalytic subunit of protein kinase A (PKA) from the inhibitory influence of its regulatory subunit, which then migrates into the nucleus to phosphorylate and enhance the binding of relevant transcription factors to the promoter element CRE of genes involved in above cellular responses. This review summarizes the available data on the essential role of this pathway in embryonic development as well as the functionality, ontogeny and consequences of genetic and chemical disruption of this pathway in the developing orofacial structures, especially the secondary palate as influenced by the mycotoxin, secalonic acid D.
引用
收藏
页码:235 / 242
页数:8
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