Disseminated Bacillus Calmette-Guerin Disease after BCG Vaccination: A Case Report from China

被引：0
|
作者：
Ling, Luoya [1 ]
Wang, Youqing [2 ]
Ding, Ye [2 ]
Zheng, Lin [3 ]
Qi, Xiaohua [1 ]
Jin, Mingjuan [2 ]
Chen, Kun [2 ]
Xie, Shuyun [1 ]
机构：
[1] Zhejiang Ctr Dis Control & Prevent, Inst Immunizat & Prevent, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hangzhou 310003, Zhejiang, Peoples R China
[3] Xihu Dist Ctr Dis Control & Prevent, Inst Immunizat & Prevent, Hangzhou, Zhejiang, Peoples R China
来源：
IRANIAN JOURNAL OF IMMUNOLOGY | 2015年 / 12卷 / 01期
关键词：
Bacillus Calmette-Guerin (BCG); Immunodeficiency; Pathogen infection; Tuberculosis; Vaccination;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: Bacillus Calmette-Guerin (BCG) vaccination is recommended for newborn infants worldwide to prevent tuberculosis. However, complications do occur inevitably in a very low rate, among which the most serious is disseminated disease. The disseminated bacillus Calmette-Guerin disease is a rare disease with high fatality, and can be seen among persons with an underlying immunodeficiency. Case presentation: We report a 4-month-old male infant presenting with recurrent fever, an isolated left axillary massand swelling at the site of BCG inoculation. The cellular immune function analysis showed that the value of CD4/CD8 was 0.994, indicating the existence of immunodeficiency. The results of blood culture and throat swab culture showed conditional pathogen infection. He died of cardiopulmonary failure. Conclusion: In this case, necropsy played a significant role in the final diagnosis of disseminated pulmonary tuberculosis.
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页码：70 / 73
页数：4
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