Staphylococcus aureus Pore-Forming Toxins

被引：29

作者：

Reyes-Robles, Tamara ^{[1
]}

Torres, Victor J. ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Microbiol, Microbial Pathogenesis Program, 522 First Ave,Smilow Res Bldg,Room 1010, New York, NY 10016 USA

来源：

STAPHYLOCOCCUS AUREUS: MICROBIOLOGY, PATHOLOGY, IMMUNOLOGY, THERAPY AND PROPHYLAXIS | 2017年 / 409卷

关键词：

PANTON-VALENTINE LEUKOCIDIN; LEUCOTOXIN S-COMPONENT; ALPHA-TOXIN; GAMMA-HEMOLYSIN; CRYSTAL-STRUCTURE; LUKE-LUKD; SEQUENTIAL BINDING; BICOMPONENT TOXIN; LEUCOCIDIN; IRON;

D O I：

10.1007/82_2016_16

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Staphylococcus aureus (S. aureus) is a formidable foe equipped with an armamentarium of virulence factors to thwart host defenses and establish a successful infection. Among these virulence factors, S. aureus produces several potent secreted proteins that act as cytotoxins, predominant among them the beta-barrel pore-forming toxins. These toxins play several roles in pathogenesis, including disruption of cellular adherens junctions at epithelial barriers, alteration of intracellular signaling events, modulation of host immune responses, and killing of eukaryotic immune and non-immune cells. This chapter provides an updated overview on the S. aureus beta-barrel pore-forming cytotoxins, the identification of toxin receptors on host cells, and their roles in pathogenesis.

引用

页码：121 / 144

页数：24

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