Microwave-enhanced Fischer reaction:: An efficient one-pot synthesis of γ-carbolines

被引：13

作者：

Chen, Jing ^{[1
]}

Chen, Weiliang ^{[1
]}

Hu, Yongzhou ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Peoples R China

来源：

SYNLETT | 2008年 / 01期

关键词：

gamma-carbolines; N-acetyl-3-bromo-4-piperidone hydrobromide; arylhydrazine hydrochloride; Fischer reaction; microwave irradiation;

D O I：

10.1055/s-2007-99241

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

gamma-Carbotines were obtained in a simple one-pot Fischer reaction starting from N-acetyl-3-bromo-4-piperidone hydrobromide and substituted arylhydrazine hydrochlorides in acidic media under microwave irradiation or by a thermal process. The optimization procedures are reported in detail, and the results from microwave processes are compared with conventional ones.

引用

页码：77 / 82

页数：6

共 50 条

[21] Efficient copper(I)-catalyzed, microwave-assisted, one-pot synthesis of 3,4-diaryl isoquinolines [J].

Hu, Zhang ;

Ou, Li-Li ;

Li, Si-Dong ;

Yang, Lei .

RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (06) :3461-3469

[22] Azines from one-pot reaction of thiosemicarbazones [J].

Aly, Ashraf A. ;

Hassan, Alaa A. ;

Brown, Alan B. ;

Ibrahim, Mahmoud A. A. ;

AbdAl-Latif, El-Shimaa S. M. .

JOURNAL OF SULFUR CHEMISTRY, 2017, 38 (01) :11-17

[23] A highly efficient and reusable heterogeneous catalyst for the one-pot synthesis of tetrasubstituted imidazoles [J].

Mohammadi, Ali ;

Keshvari, Hossein ;

Sandaroos, Reza ;

Maleki, Behrooz ;

Rouhi, Hamed ;

Moradi, Hassanali ;

Sepehr, Zeinalabedin ;

Damavandi, Saman .

APPLIED CATALYSIS A-GENERAL, 2012, 429 :73-78

[24] Efficient Synthesis of Dicycloalkenopyridines:One-pot Multicomponent Condensation of Aldehydes with Cyclic Ketones [J].

CAI Ximei WANG Qifang and YAN Chaoguo College of Chemistry Chemical Engineering Yangzhou University Yangzhou P R China .

Chemical Research in Chinese Universities, 2009, 25 (05) :657-661

[25] Efficient Synthesis of Dicycloalkenopyridines: One-pot Multicomponent Condensation of Aldehydes with Cyclic Ketones [J].

Cai Xi-mei ;

Wang Qi-fang ;

Yan Chao-guo .

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2009, 25 (05) :657-661

[26] One-pot synthesis of N-substituted azapodophyllotoxin derivatives under microwave irradiation [J].

Tu, Shujiang ;

Zhang, Yan ;

Jiang, Bo ;

Jia, Runhong ;

Zhang, Junyong ;

Zhang, Jinpeng ;

Ji, Shunjun .

SYNTHESIS-STUTTGART, 2006, (22) :3874-3882

[27] One-pot synthesis of iminoimidazolines under microwave irradiation in solvent-free conditions [J].

Servi, Sueleyman ;

Genc, Murat .

SYNTHETIC COMMUNICATIONS, 2007, 37 (18) :3173-3179

[28] Indium-mediated microwave-assisted one-pot synthesis of α,β-unsaturated amides [J].

Feng, Sunlin ;

Jiang, Shilei ;

Zhang, Zhiying ;

Yu, Xiaochun .

JOURNAL OF CHEMICAL RESEARCH, 2010, (07) :392-394

[29] Microwave-promoted one-pot three-component reaction to [60]Fulleropyrrolidine derivatives [J].

Zhang, JM ;

Yang, W ;

Wang, S ;

He, P ;

Zhu, SH .

SYNTHETIC COMMUNICATIONS, 2005, 35 (01) :89-96

[30] Microwave assisted novel one-pot three-component reaction for synthesis of 3-aminoimidazopyridines using molecular iodine [J].

Shareef, Sumbulunnisan ;

Saigal ;

Khizr, Mohammad ;

Sahoo, Subash C. ;

Khan, Md Musawwer .

TETRAHEDRON LETTERS, 2021, 84

← 1 2 3 4 5 →