Microwave-enhanced Fischer reaction:: An efficient one-pot synthesis of γ-carbolines

被引：13

作者：

Chen, Jing ^{[1
]}

Chen, Weiliang ^{[1
]}

Hu, Yongzhou ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Peoples R China

来源：

SYNLETT | 2008年 / 01期

关键词：

gamma-carbolines; N-acetyl-3-bromo-4-piperidone hydrobromide; arylhydrazine hydrochloride; Fischer reaction; microwave irradiation;

D O I：

10.1055/s-2007-99241

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

gamma-Carbotines were obtained in a simple one-pot Fischer reaction starting from N-acetyl-3-bromo-4-piperidone hydrobromide and substituted arylhydrazine hydrochlorides in acidic media under microwave irradiation or by a thermal process. The optimization procedures are reported in detail, and the results from microwave processes are compared with conventional ones.

引用

页码：77 / 82

页数：6

共 29 条

[1]

ACRAMONE F, 1989, ANTITUMOR NATURAL PR, P1

[2]

Bremer O, 1934, LIEBIGS ANN CHEM, V514, P279

[3] THE FISCHER INDOLE SYNTHESIS .4. HALOGEN INTERCHANGE DURING THE ZINC HALIDE INDUCED FISCHER REACTIONS OF ACETOPHENONE 2,6-DIHALOPHENYLHYDRAZONES [J].