The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases

被引：142

作者：

Balacescu, Ovidiu ^{[1
,2
]}

Sur, Daniel ^{[2
,3
]}

Cainap, Calin ^{[2
,3
]}

Visan, Simona ^{[1
]}

Cruceriu, Daniel ^{[1
,4
]}

Manzat-Saplacan, Roberta ^{[5
,6
]}

Muresan, Mihai-Stefan ^{[7
,8
]}

Balacescu, Loredana ^{[1
,2
]}

Lisencu, Cosmin ^{[8
,9
]}

Irimie, Alexandru ^{[8
,9
]}

机构：

[1] Oncol Inst Prof Dr Ion Chiricuta, Dept Funct Genom Prote & Expt Pathol, Cluj Napoca 400015, Romania

[2] Univ Med & Pharm Iuliu Hatieganu, Dept Med Oncol 11, Cluj Napoca 400015, Romania

[3] Oncol Inst Prof Dr Ion Chiricuta, Dept Med Oncol, Cluj Napoca 400015, Romania

[4] Babes Bolyai Univ, Dept Mol Biol & Biotechnol, Cluj Napoca 400006, Romania

[5] Univ Med & Pharm Iuliu Hatieganu, Dept Internal Med 5, Cluj Napoca 400006, Romania

[6] Wilhelmina Hosp Assen, Dept Gastroenterol, Europaweg Zuid 1, NL-9401 RK Assen, Netherlands

[7] Univ Med & Pharm Iuliu Hatieganu, Municipal Hosp, Dept Surg, Cluj Napoca 400139, Romania

[8] Univ Med & Pharm Iuliu Hatieganu, Dept Oncol Surg & Gynecol Oncol 11, Cluj Napoca 400015, Romania

[9] Oncol Inst Prof Dr Ion Chiricuta, Dept Surg, Cluj Napoca 400015, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 12期

关键词：

miRNAs; colorectal cancer; exosomes; liver; metastases; EPITHELIAL-MESENCHYMAL-TRANSITION; HEPATOCELLULAR-CARCINOMA CELLS; WNT/BETA-CATENIN PATHWAY; TUMOR-SUPPRESSOR P53; COLON-CANCER; BETA-CATENIN; NEGATIVE REGULATION; PROMOTES MIGRATION; FEEDBACK LOOP; EXPRESSION;

D O I：

10.3390/ijms19123711

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies with a high incidence and mortality rate. An essential challenge in colorectal cancer management is to identify new prognostic factors that could better estimate the evolution and treatment responses of this disease. Considering their role in cancer development, progression and metastasis, miRNAs have become an important class of molecules suitable for cancer biomarkers discovery. We performed a systematic search of studies investigating the role of miRNAs in colorectal progression and liver metastasis published until October 2018. In this review, we present up-to-date information regarding the specific microRNAs involved in CRC development, considering their roles in alteration of Wnt/beta catenin, EGFR, TGF beta and TP53 signaling pathways. We also emphasize the role of miRNAs in controlling the epithelial-mesenchymal transition of CRC cells, a process responsible for liver metastasis in a circulating tumor cell-dependent manner. Furthermore, we discuss the role of miRNAs transported by CRC-derived exosomes in mediating liver metastases, by preparing the secondary pre-metastatic niche and in inducing liver carcinogenesis in a Dicer-dependent manner.

引用

页数：22

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