Role of host-defence peptides in eye diseases

被引：40
作者：
Kolar, Satya S. [1 ]
McDermott, Alison M. [1 ]
机构：
[1] Univ Houston, Coll Optometry, Houston, TX 77204 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 13期
基金：
美国国家科学基金会;
关键词：
Defensin; Cathelicidin; Keratitis; Dry eye; Contact lens; HUMAN BETA-DEFENSINS; IN-VITRO ACTIVITY; CORNEAL EPITHELIAL-CELLS; AMINO-ACID TRANSPORTERS; INNATE IMMUNE-RESPONSE; COPY NUMBER VARIATION; ANTIMICROBIAL PEPTIDES; CATHELICIDIN LL-37; GENE-EXPRESSION; FUNGAL KERATITIS;
D O I：
10.1007/s00018-011-0713-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The eye and its associated tissues including the lacrimal system and lids have evolved several defence mechanisms to prevent microbial invasion. Included among this armory are several host-defence peptides. These multifunctional molecules are being studied not only for their endogenous antimicrobial properties but also for their potential therapeutic effects. Here the current knowledge of host-defence peptide expression in the eye will be summarised. The role of these peptides in eye disease will be discussed with the primary focus being on infectious keratitis, inflammatory conditions including dry eye and wound healing. Finally the potential of using host-defence peptides and their mimetics/derivatives for the treatment and prevention of eye diseases is addressed.
引用
收藏
页码：2201 / 2213
页数：13
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