Modular construction of multifunctional ligands for the enantioselective ruthenium-catalyzed carbenoid N-H insertion reaction: an enzyme-like and substrate-sensitive catalyst system

被引：17

作者：

Huang, Wei-Sheng ^{[1
]}

Xu, Zheng ^{[1
]}

Yang, Ke-Fang ^{[1
]}

Chen, Li ^{[1
]}

Zheng, Zhan-Jiang ^{[1
]}

Xu, Li-Wen ^{[1
,2
,3
]}

机构：

[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 310012, Zhejiang, Peoples R China

[2] Shaanxi Normal Univ, Minist Educ MOE, Key Lab Appl Surface & Colloid Chem, Xian 710062, Peoples R China

[3] Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710062, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 58期

基金：

中国国家自然科学基金;

关键词：

AROMATIC-ALDEHYDES; ETHYL DIAZOACETATE; ASYMMETRIC-SYNTHESIS; MECHANISTIC INSIGHT; RHODIUM CARBENOIDS; DIAZO-COMPOUNDS; AMINO-ACID; BONDS; CYCLOPROPANATION; HYDROGENATION;

D O I：

10.1039/c5ra05804j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It was found for the first time that cinchonine-and BINOL-derived multifunctional ligands bearing a siliconbased bulky group exhibited promising enantioselective control in the ruthenium-catalysed carbenoid N-H insertion reaction, in which the Ru-L26 system with multiple stereogenic centers was proved to be an enzyme-like catalyst because it exhibited a narrow substrate scope and size-sensitive discrimination in this reaction.

引用

页码：46455 / 46463

页数：9