Antiviral activity of maca (Lepidium meyenii) against human influenza virus

被引：30

作者：

del Valle Mendoza, Juana ^{[1
]}

Pumarola, Tomas ^{[2
]}

Alzamora Gonzales, Libertad ^{[3
]}

del Valle, Luis J. ^{[1
,4
]}

机构：

[1] Univ Peruana Ciencias Aplicadas UPC, Fac Ciencias Salud, Escuela Med, Ctr Invest, Lima, Peru

[2] Hosp Vail dHebron, Serv Microbiol, Barcelona 08035, Spain

[3] Univ Nacl Mayor San Marcos, Fac Ciencias Biol, Dept Acad Microbiol & Parasitol, Lima 1, Peru

[4] Univ Politecn Cataluna, Ctr Biotecnol Mol CEBIM, ETSEIB, Dept Engn Quim, E-08028 Barcelona, Spain

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2014年 / 7卷

关键词：

Influenza virus; Flu; Antiviral activity; Lepidium meyenii; Maca; A VIRUS; INFECTIONS; INHIBITORS; RELEVANCE; MEDICINE;

D O I：

10.1016/S1995-7645(14)60268-6

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To investigate antiviral activity of maca to reduce viral load in Madin-Darby canine kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and Flu-B, respectively). Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the extracts were evaluated on MDCK cells using method MTT assay. Antiviral activity of compounds against Flu-A and Flu-B viruses was assayed using a test for determining the inhibition of the cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits.

引用

页码：S415 / S420

页数：6

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